Results 41 to 50 of about 19,404,997 (303)

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

El hedor en la Nueva España: sensibilidad olfativa ante el fenómeno de la otredad (siglo XVI)

open access: yesHistoria Crítica
Objective/Context: This article aims to analyze the olfactory descriptions of blood, the Indigenous, and their idols in sacrificial narratives in four early modern American sources (sixteenth century): Letters of Relation by Hernán Cortés, The Vision of ...
Ingrid Sánchez Téllez
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

The Villancio in New Spain 1650-1750: morphology, significance and development [PDF]

open access: yes, 2014
For almost three centuries, the sacred villancico was the primary vernacular musical form of Spain and its New World colonies. Consisting of a through-composed estribillo, or refrain, and a set of strophic coplas, or verses, these ‘devout and honest ...
Swadley, J.
core  

L’intendance aux mains des Créoles : une réalité politique indiscutable

open access: yesNuevo mundo - Mundos Nuevos, 2017
This text is an extract of the second part of my thesis The intendants of the viceroyalty of New Spain (1764-1821): origins, careers y colonial integration. Prosopographical test.
Marie-Pierre Lacoste
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Leiolima iberica, a new harvestman genus and species from the Iberian Peninsula (Arachnida, Opiliones, Sclerosomatidae)

open access: yesEuropean Journal of Taxonomy, 2020
Recent studies have shown that the speciose Holarctic genera of Leiobunum C.L. Koch, 1839 and Nelima Roewer, 1910 are polyphyletic taxa, and therefore, the traditional diagnostic characters for these European genera of Leiobuninae Banks, 1893 ...
Carlos E. Prieto, Hay Wijnhoven
doaj   +1 more source

The New Regulation of Abortion in Spain

open access: yesEuropean Journal of Health Law, 2011
AbstractThe enactment of Law 2/2010 on Sexual and Reproductive Health and on Voluntary Interruption of Pregnancy represents a radical change in the regulation of abortion in Spain. The law moves from the medical indication model that has been in place since 1985 (which established certain cases in which abortion was legal) towards a time-limit model ...
openaire   +3 more sources

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

open access: yesFEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez   +6 more
wiley   +1 more source

LOCALISING AND GLOBALISING THE DEPOPULATION DIVIDEND: THEORY AND EVIDENCE FROM THREE COUNTRIES IN THREE WORLD REGIONS

open access: yesBölge Çalışmaları Dergisi, 2022
We bring together evidence from three countries in differing world regions to ask whether or how depopulation is delivering socio-environmental gains – what we call a ‘depopulation dividend’. We first discuss the depopulation problem itself and introduce
Peter Matanle   +3 more
doaj  

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