Results 41 to 50 of about 2,298,846 (310)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Tradition and Political Economy in the Viceroyalty of New Spain (18th century)
Ибероамериканские тетрадиThe legal traditions of the Spanish Empire, which had certain particularities but were always in line with the imperial Catholic culture, played a major role in the development and expansion of the Hispanic world in the Ancien Régime.
J. R. Bravo
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Descriptions of two new species of the family Scythrididae from Europe (Lepidoptera: Scythrididae)
SHILAP, 2019 Two new species of the family Scythrididae are described from Europe: Scythris spiniferella Nupponen & Savenkov, sp. n. from Southern Spain, and Scythris rowecki Nupponen & Savenkov, sp. n. from the Southern Ural Mountains, Russia.
K. Nupponen, N. Savenkov
doaj +1 more source
EU Cohesion policy 2007-13 and the implications for Spain : who gets what, when and how? [PDF]
, 2006 The recent negotiation of the EU budget and the associated reform of EU Cohesion policy have had major policy implications for Spain, the country in receipt of most Cohesion policy support in the current programming period (2000-06).
Delgado, M.J. +6 more
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
European Journal of Taxonomy, 2020 Recent studies have shown that the speciose Holarctic genera of Leiobunum C.L. Koch, 1839 and Nelima Roewer, 1910 are polyphyletic taxa, and therefore, the traditional diagnostic characters for these European genera of Leiobuninae Banks, 1893 ...
Carlos E. Prieto, Hay Wijnhoven
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source