Results 51 to 60 of about 19,404,997 (303)

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li   +11 more
wiley   +1 more source

Evaluación de nuevos medicamentos en España y comparación con otros países europeos

open access: yes, 2019
Objetivo: Comparar el uso de la evaluación de tecnologías sanitarias (ETS) como instrumento para apoyar la fijación de precios y el reembolso de nuevos medicamentos en España con otros países europeos como Inglaterra, Suecia, Francia y Alemania.
Espín, Jaime, Epstein, David
core   +1 more source

La Conquista y la Colonia en el Códice Azcatitlan

open access: yesJournal de la Société des Américanistes, 2012
The Conquest and the Colony in the Codex Azcatitlan. The Codex Azcatitlan is a pictographic document from Central Mexico that contains three historical sections.
María Castañeda de la Paz   +1 more
doaj   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller   +14 more
wiley   +1 more source

Factors influencing the location of new motorways: the large scale motorway building in Spain [PDF]

open access: yes, 2011
Since the 1980's Spain has developed an ambitious road building programme with the construction of approximately 12,000 kilometers of new motorways. This article analysis the factors related to the placement of these new motorways during two distinct ...
Holl, Adelheid
core  

Construyendo diferencias: categorías anacrónicas  y herramientas analíticas en el estudio de la sociedad novohispana del siglo XVI

open access: yesNuevo mundo - Mundos Nuevos, 2012
Using categories such as "ethnicity" or "race", sixteenth century New Spain historiography has sought to account for an alleged "social reality" of the period, which would be characterized by the opposition of two groups "essentially" different: Indians ...
Alfredo Nava Sánchez
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Vers une meilleure connaissance des intendants intérimaires de la vice-royauté de la Nouvelle-Espagne

open access: yesNuevo mundo - Mundos Nuevos, 2018
During the period 1764-1821, 196 men served as intendants in the viceroyalty of New Spain. Among these men, one hundred were appointed provisionaly. This important presence of temporary intendants isn’t a specific fact in the intendancy because we find ...
Marie-Pierre Lacoste
doaj   +1 more source

Interaction of Intraprocedural Antiplatelets and Intravenous Thrombolysis in Acute Intracranial Stenting: RESISTANT Registry Subanalysis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes   +75 more
wiley   +1 more source

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