Results 101 to 110 of about 2,056,217 (299)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

Description of Mesopolobus askewi sp. nov. (Hymenoptera, Pteromalidae), with notes on the fauna of Asaphesinae and Pteromalidae (Hymenoptera, Chalcidoidea) collected from foliage of Picea abies (L.) H. Karst. in Bulgaria [PDF]

open access: yesBiodiversity Data Journal
Mesopolobus Westwood, 1833 consists of about 135 valid species worldwide. After the fundamental monograph of Graham (1969), 12 species have been described from continental Europe and three species have been described from the Canary Islands and Malta ...
Ivaylo Todorov   +3 more
doaj   +3 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Stygocladius multisetosus gen. nov., sp. nov., a rheophilic element, inhabiting basaltic and karstic helocrenes in France and Algeria (Diptera: Chironomidae)

open access: yesFauna Norvegica, 2012
Diagnoses and descriptions of the adults and pupal exuviae of Stygocladius multisetosus gen. nov., sp. nov., are provided based primarily on male and female pharates collected in temporary basaltic and karstic helocrenes in southern France and Algeria ...
Joel Moubayed-Breil   +2 more
doaj   +1 more source

A New Species Of Pyrenochæta [PDF]

open access: yesTransactions of the Botanical Society of Edinburgh, 1917
n ...
openaire   +2 more sources

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

open access: yesMolecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul   +11 more
wiley   +1 more source

Catalogue of fungi in China 7. New taxa of lichen-forming fungi

open access: yesMycology
China has high fungal diversity and needs to be continuously explored. In this study, we focused on lichen-forming fungi and reported 18 new taxa, including one new order, viz. Polysporiales, one new family, viz.
Qiu-Xia Yang   +7 more
doaj   +1 more source

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