Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Analysis and validation of CFD simulations for flow in the large power station flue gas system [PDF]
EPJ Web of ConferencesThis paper deals with complex CFD simulations of flows in the flue gas system of a large power plant during operation. The aim of the published results is to present generalising knowledge obtained from complex simulations in the power station and show ...
Matas Richard +2 more
doaj +1 more source
The search for innovators and early adopters of e-collaborative technologies within small and medium sized enterprises in the UK [PDF]
, 2007 New product diffusion theory predicts that innovators and early adopters are critical to the success of new innovations. The rate at which enterprises adopt e-Science technologies must therefore rely upon reliable market intelligence so that the critical
Brown, D H +3 more
core
Transgressive technologies? Strategies of discursive containment in the representation and regulation of assisted reproductive technologies in Aotearoa/New Zealand [PDF]
, 2006 Drawing on a case study of the contemporary representation and regulation of assisted reproductive technologies (ARTs) in Aotearoa/New Zealand, this article traces the cultural anxieties evident in public, political, and media discussion and debate ...
Michelle, Carolyn
core +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
New frequencies, new monitoring technology
Nursing Management (Springhouse), 2003 Regulatory changes in available frequencies for wireless patient monitoring require many hospitals to implement new monitoring systems. Choose the best features of current technology, while allowing for future advances in both on- and off-site patient monitoring.
openaire +3 more sources
Industry Evolution: New Technologies and New Firms [PDF]
This paper investigates the effects of employee mobility on industry evolution and technology diffusion by testing a dynamic industry equilibrium model introduced in Franco and Filson (1999).
April Mitchell Franco, Darren Filson
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Scientific ReportsRegulation of the Hedgehog pathway activity may be supported by coactivators and corepresors of its main effectors- Gli transcription factors. While activation processes are well studied, repression mechanisms remain elusive.
Weronika Skarżyńska +2 more
doaj +1 more source