Results 121 to 130 of about 26,142,130 (292)

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Accounts of the New York Trade School for the Season of 1914-1915 [PDF]

, 1915
Financial report from the 1914-1915 school year of the New York Trade ...
New York Trade School
core  

Phase‐Dependent Oxygen Defect Energetics in Epitaxial NbN/AlN/NbN Films

Advanced Science, EarlyView.
Phase dependent oxygen defect energetics in epitaxial δ‐NbN/AlN/δ‐NbN and β‐Nb2N/AlN/β‐Nb2N trilayers. Atomic‐scale analysis and first‐principles calculations reveal distinct oxygen incorporation pathways across NbN polymorphs. Layer resolved defect formation energies show that O is energetically more favorable within δ‐NbN electrodes, whereas in β ...
Prachi Garg, Kedarsh Kaushik, Danqing Wang, Naomi Pieczulewski, Anand Ithepalli, John Wright, Debdeep Jena, David A. Muller, Hong X. Tang, Cyrus Dreyer, Baishakhi Mazumder   +10 more
wiley   +1 more source

Standards for Computational Methods in Drug Design and Discovery: Simplified Guidance for Authors and Reviewers

Drug Design, Development and Therapy
Tamer M Ibrahim,1,2 Muzammal Hussain,3,4 Frank M Boeckler5,6 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt; 2Center for Informatics Science (CIS), School of Information Technology and ...
Ibrahim TM, Hussain M, Boeckler FM
doaj  

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Quality or Quantity? The Quiet Influence of Industry-Sponsored Centers of Excellence

Journal of Pain Research
Scott G Pritzlaff,1 Victoria Flower,2 Vafi Salmasi,3 Samir J Sheth,2 Michael E Schatman4,5 1Department of Anesthesiology and Pain Medicine, University of California, Davis, Sacramento, CA, USA; 2Sutter Neuroscience Institute, Interventional Pain Medicine,
Pritzlaff SG, Flower V, Salmasi V, Sheth SJ, Schatman ME   +4 more
doaj  

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Welding Equipment at the New York Trade School

, 2015
Pictured is a P & H A.C. Arc Welder that would have been used to teach students in the Welding Department at the New York Trade School.
New York Trade School
core   +1 more source

Hydraulic Pressure‐Programmed Molecular Transport in Tough Hydrogels

Advanced Science, EarlyView.
Hydraulic pressure is introduced as a programmable parameter for regulating molecular transport in tough hydrogel membranes. Reversing the pressure direction accelerates or slows transport, tuning characteristic transport times over a 65‐fold range while achieving molecular separation and controlled delivery.
Yijie Cheng, Shahd Alnasser, Akhiri Zannat, Zhenda He, Jiayi Zeng, Lenan Zhang, Sungmin Hong, Xinyue Liu   +7 more
wiley   +1 more source

Bilateral spermatocytic seminoma: a case report

Research and Reports in Urology, 2014
Hadley Narins,1 Kent Chevli,1,2 Richard Gilbert,2 Michael Duff,1,2 Andrew Toenniessen,2 Yan Hu31Department of Urology, State University of New York at Buffalo Medical School, Buffalo, NY, USA; 2Western New York Urology Associates, Cheektowaga, NY, USA ...
Narins H, Chevli K, Gilbert R, Duff M, Toenniessen A, Hu Y   +5 more
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