Results 151 to 160 of about 636,620 (264)
Building Capacity on Hypertension Management in Nigeria.
JAMA Netw OpenMishra S, Ekanem A, Henry D, Idang E, Ituen I, Okon S, Ekpoudom D, Chen W, Onakomaiya D, Kanneh N, Lew D, Hade EM, Aifah AA, Attah EA, Ogedegbe G, Ojji D. +15 moreeuropepmc +1 more sourceAppropriate Medical Therapy Primarily Modifies Type 2 and Severity Biomarkers in Chronic Rhinosinusitis
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background
Appropriate medical therapy (AMT) is first‐line treatment for patients with chronic rhinosinusitis (CRS). We evaluated inflammatory structure, treatment‐induced changes, and biomarker‐outcome associations in AMT‐managed patients. Methods
Fifty‐one CRS patients were evaluated before and after AMT which included a combination of oral ...Asher C. Park, Brooke N. Gleason, Eli Stein, Saied Ghadersohi, Atsushi Kato, Stephanie Shintani‐Smith, David B. Conley, Kevin C. Welch, Robert C. Kern, Bruce K. Tan +9 morewiley +1 more sourceIndividualized Atrophy‐Based Prediction of Dementia Progression in Familial Frontotemporal Lobar Degeneration With Bayesian Linear Mixed‐Effects Modeling
Annals of Neurology, EarlyView.Objective
Age of symptom onset is highly variable in familial frontotemporal lobar degeneration (f‐FTLD). Accurate prediction of onset would inform clinical management and trial enrollment. Prior studies indicate that individualized maps of brain atrophy can predict conversion to dementia in f‐FTLD.Shubir Dutt, Dana Leichter, Yann Cobigo, Amy Wolf, John Kornak, Annie Clark, Lucy L. Russell, Arabella Bouzigues, David M. Cash, Martina Bocchetta, Molly Olzinski, Brian Appleby, Ece Bayram, Barbara Borroni, Andrea Bozoki, Chris R. Butler, David Clark, Rhian S. Convery, R. Ryan Darby, Alexandre de Mendonça, Bradford Dickerson, Kimiko Domoto‐Reilly, Simon Ducharme, Eve Ferry‐Bolder, Elizabeth Finger, Phoebe H. Foster, Douglas R. Galasko, Daniela Galimberti, Alexander Gerhard, Nupur Ghoshal, Caroline Graff, Neill Graff‐Radford, Ian M. Grant, Chadwick M. Hales, Lawrence S. Honig, Ging‐Yuek Hsiung, Edward D. Huey, David Irwin, Lize C. Jiskoot, Walter Kremers, Justin Y. Kwan, Robert Laforce, Isabelle Le Ber, Gabriel C. Léger, Johannes Levin, Irene Litvan, Ian R. Mackenzie, Mario Masellis, Mario F. Mendez, Fermin Moreno, Chiadi Onyike, Markus Otto, Belen Pascual, Peter Pressman, Rosa Rademakers, Eliana Marisa Ramos, Aaron Ritter, Erik D. Roberson, James B. Rowe, Raquel Sanchez‐Valle, Isabel Santana, Harro Seelaar, Allison Snyder, Sandro Sorbi, Matthis Synofzik, Maria Carmela Tartaglia, Pietro Tiraboschi, John C. van Swieten, Marijne Vandebergh, Rik Vandenberghe, Hilary W. Heuer, Bruce L. Miller, William W. Seeley, Maria Luisa Gorno‐Tempini, Joel H. Kramer, Leah Forsberg, Kejal Kantarci, Bradley F. Boeve, Adam L. Boxer, Jonathan D. Rohrer, Howard J. Rosen, Adam M. Staffaroni, FTD Prevention Initiative (FPI) investigators +82 morewiley +1 more sourceAccelerating Catalyst Materials Discovery With Large Artificial Intelligence Models
Angewandte Chemie, EarlyView.AI‐empowered catalysis research via integrated database platform, universal machine learning interatomic potentials (MLIPs), and large language models (LLMs). ABSTRACT
The integration of artificial intelligence (AI) into catalysis is fundamentally reshaping the research paradigm of catalyst discovery.Di Zhang, Yuanzheng Chen, Chuanyu Liu, Yan Liu, Hongliang Xin, Jiayu Peng, Pengfei Ou, Hao Li +7 morewiley +2 more sourcesIndividualized Treatment in Distal and Medium Vessel Occlusion Stroke Using a Validated Explainable Counterfactual Treatment Estimation Model
Annals of Neurology, EarlyView.Objective
The optimal treatment for distal medium vessel occlusion (DMVO) stroke remains uncertain, and evidence comparing endovascular therapy (EVT) with medical management (MM) is limited. We aimed to develop and validate a predictive modeling tool to assess individual treatment benefit in DMVO stroke using explainable counterfactual treatment ...Mohamed F. Doheim, Mahmoud H. Mohammaden, Hend Abdelhamid, Marta Olive‐Gadea, Marc Rodrigo‐Gisbert, Manuel Requena, Johanna T. Fifi, James E. Siegler, Santiago Ortega‐Gutierrez, Mohamad Abdalkader, Ali Alaraj, Wei Hu, Thanh N. Nguyen, Diogo C. Haussen, Raul G. Nogueira +14 morewiley +1 more sourceGenetic Testing for APOL1 in Adults With Hypertension: The GUARDD-US Randomized Clinical Trial.
JAMA Netw OpenEadon MT, Cavanaugh KL, She L, Steen-Burrell KA, Mohottige D, Nadkarni GN, Kitzman H, Chakraborty H, Empey PE, Limdi NA, Singh R, Beasley CM, Parker AS, Cicali EJ, Ramos MA, Clermont S, Dodgen L, Elwood EN, Robinson M, Umeukeje EM, Garcia Ortega A, Shroff N, Rosenman MB, Nguyen KA, Volpi S, Rider R, Dexter PR, Skaar TC, Peterson JF, Cavallari LH, Johnson JA, Wyatt CM, Orlando LA, Cooper-DeHoff RM, Horowitz CR, Implementing Genomics in Practice (IGNITE) Pragmatic Trials Network. +35 moreeuropepmc +1 more sourceSocial Determinants of Health and Pediatric Long COVID in the US. [PDF]
JAMA PediatrRhee KE, Thaweethai T, Pant DB, Stein CR, Salisbury AL, Kinser PA, Kleinman LC, Gallagher R, Warburton D, Mohandas S, Snowden JN, Stockwell MS, Tantisira KG, Flaherman VJ, Teufel RJ, Castro L, Chung A, Espinoza Esparza J, Hockett CW, Isidoro-Chino M, Krishnan A, McCormack LA, Nabower AM, Nahin ER, Rosas JM, Siddiqui S, Szmuszkovicz JR, Vangeepuram N, Zimmerman E, Brown HE, Carmilani M, Coombs K, Fisher L, Witvliet MG, Wood JC, Milner JD, Rosenzweig EB, Irby K, Karlson EW, Qian Z, Lamendola-Essel MF, Hasson DC, Katz SD, Yin HS, Foulkes AS, Gross RS, RECOVER-Pediatrics Group; and the ABCD-RECOVER Group; for the RECOVER-Pediatrics Consortium
, Aschner JL, Atz AM, Banerjee D, Bogie A, Bukulmez H, Clouser K, Cottrell LA, Cowan K, D'Sa VA, Dozor AJ, Elliott AJ, Faustino EVS, Fiks AG, Gaur S, Gennaro ML, Gordon ST, Hasan UN, Hester CM, Hogan AH, Hsia DS, Kaelber DC, Kosut JS, Krishnan S, McCulloh RJ, Michelow IC, Nolan SM, Oliveira CR, Pace WD, Palumbo P, Raissy H, Reyes A, Ross JL, Salazar JC, Selvarangan R, Stevenson MD, Werzberger A, Westfall JM, Zani K, Zempsky WT, Chan J, Metz TD, Newburger JW, Truong DT, Feldman CH, Aupperle R, Baker FC, Banich MT, Barch DM, Baskin-Sommers A, Bjork JM, Dapretto M, Brown SA, Casey BJ, Chang L, Clark DB, Dale AM, Ernst TM, Fair DA, Feldstein Ewing SW, Foxe JJ, Freedman EG, Friedman NP, Garavan H, Gee DG, Gonzalez R, Gray KM, Heitzeg MM, Herting MM, Jacobus J, Laird AR, Larson CL, Lisdahl KM, Luciana M, Luna B, Madden PAF, McGlade EC, Müller-Oehring EM, Nagel BJ, Neale MC, Paulus MP, Potter AS, Renshaw PF, Sowell ER, Squeglia LM, Uddin LQ, Wilson S, Yurgelun-Todd DA. +133 moreeuropepmc +1 more sourceDiverse Genetic Etiologies of Unilateral Polymicrogyria
Annals of Neurology, EarlyView.Objective
Polymicrogyria (PMG) is one of the most common human malformations of cortical development and is often classified by its radiographic pattern of distribution. Unilateral polymicrogyria (uPMG) is a subtype of PMG affecting a portion or all of one cerebral hemisphere.Abbe Lai, Jennifer E. Neil, Shyam K. Akula, Dina Amrom, Eva Andermann, Ann Bergin, Roberto Caraballo, Allen Y. Chen, John Gaitanis, Ganeshwaran H. Mochida, Jill M. Gotoff, Giorgi Kuchukhidze, Daphna Marom, Christelle Moufawad ElAchkar, Miriam Regev, Lance H. Rodan, Heather Olson, Bo Zhang, Annapurna Poduri, Diane D. Shao, Christopher A. Walsh, Edward Yang +21 morewiley +1 more sourceNovel Monoclonal Antibody Detects Small Aβ Oligomers More Sensitively Than Lecanemab in Alzheimer's Disease CSF, Serum and Culture Media
Annals of Neurology, EarlyView.Objective
Aqueously diffusible oligomers of the amyloid β‐protein (oAβ) are neurotoxic and play a role in neuronal dysfunction in Alzheimer's disease (AD). Accurate quantification of oAβ in brains and biofluids could be valuable for understanding and monitoring AD.Yi Ran Xu, Youqi Tao, Alexandra M. Lish, Shaomin Li, Beth L. Ostaszewski, Amirah K. Anderson, Tracy Young‐Pearse, Trebor L. Lawton, Hyun‐Sik Yang, Dominic M. Walsh, Ting Yang, Dennis J. Selkoe +11 morewiley +1 more source
