Results 91 to 100 of about 524,540 (290)

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

Design of Portable New Intelligence Thermometer for Newborn Household

, 2020

openalex   +1 more source

Tim1 Deficiency Mediates Gestational Hyperglycemia‐Related Syncytiotrophoblast Dysfunction and Fetal Growth Restriction

Advanced Science, EarlyView.
Hyperglycemia during pregnancy impairs the fusion of trophoblast cells into syncytiotrophoblasts, leading to fetal growth restriction. This impaired fusion is mediated by Tim1 downregulation via hyperglycemia‐induced ROS. Antioxidant therapy during pregnancy promotes syncytiotrophoblast formation by upregulating Tim1 expression, thus alleviating fetal ...
Junsen She, Rui Liu, Chen Fang, Shuyu Zhang, Yizhi Hu, Fei Guo, Yuhang Long, Mengzhen Ding, Haiyan Wu, Bokang Zhou, Zexin Yang, Ying Jiang, Jianzhong Sheng, Ling Gao, Hefeng Huang   +14 more
wiley   +1 more source

Quality improvement project to reduce intraventricular haemorrhage in very preterm infants failed due to increased life-sustaining intensive care at low gestational age

BMJ Open Quality
Objectives In October 2016, a single centre quality improvement programme ‘IBIS’ (from the German “Intraventrikuläre Blutungs-Inzidenz Senken”), an intraventricular haemorrhage (IVH) prevention bundle had the Specific Measurable Achievable Reasonable ...
Dirk Bassler, Mark Adams, David Glauser, Isabelle Erni, Michael Wolff, Beate Grass   +5 more
doaj   +1 more source

Distinct locomotor precursors in newborn babies

, 2020
Francesca Sylos‐Labini, Valentina La Scaleia, Germana Cappellini, Fabiano Adele, Picone Simonetta, S. Keshishian Elena, Semyonov Dmitry, Paolillo Piermichele, И. А. Солопова, Andrea d’Avella, Yuri P. Ivanenko, Francesco Lacquaniti   +11 more
openalex   +1 more source

Multifactorial Colonization of the Pregnant Woman’s Reproductive Tract: Implications for Early Postnatal Adaptation in Full-Term Newborns [PDF]

, 2023
P Gibala, Anna Jarosz‐Lesz, Z Sołtysiak-Gibała, Jakub Staniczek, Rafał Stojko   +4 more
openalex   +1 more source

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, EarlyView.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

The Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow

Advanced Science, EarlyView.
This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang, Rui Zhang, Xiao‐Min Yue, Jie Zhou, Yu‐Fan Huang, Rong Meng, Yu‐Li Wang, Xiao‐Qing Li   +7 more
wiley   +1 more source

Reassessing and Extending the European Standards of Care for Newborn Health: How to Keep Reference Standards in Line with Current Evidence

Children
The European Standards of Care for Newborn Health (ESCNH) were launched in 2018. After three years, the first standards were reassessed and revised to align with current evidence. Moreover, new standards regarding emerging topics were developed.
Isabel Geiger, Johanna Kostenzer, Valerie Matthäus, on behalf of the ESCNH Chair Committee, Silke Mader, Luc J. I. Zimmermann   +5 more
doaj   +1 more source