Results 221 to 230 of about 925,982 (358)

Efficient Somatic Cell Nuclear Transfer by Overcoming Both Pre‐ and Post‐Implantation Epigenetic Barriers

open access: yesAdvanced Science, EarlyView.
Mammalian cloning via SCNT is limited by several epigenetic barriers. Kdm4d/Kdm5b overexpression plus TSA treatment overcomes epigenetic barriers during pre‐implantation development, while tetraploid complementation replaces defective extraembryonic lineages to bypass H3K27me3 imprinting loss to overcome epigenetic barriers in post‐implantation ...
Yamei Li   +13 more
wiley   +1 more source

FemXpress: Systematic Analysis of X Chromosome Inactivation Heterogeneity in Female Single‐Cell RNA‐Seq Samples

open access: yesAdvanced Science, EarlyView.
FemXpress is a computational tool that leverages X‐linked single nucleotide polymorphisms (SNPs) to group cells by the origin of the inactivated X chromosome in female single‐cell RNA sequencing (scRNA‐Seq) data. It demonstrates strong performance on both simulated and real datasets without requiring parental genomic information, and can also identify ...
Xin Wang   +15 more
wiley   +1 more source

Born too soon: accelerating change to 2030 and beyond. [PDF]

open access: yesReprod Health
Lawn JE   +16 more
europepmc   +1 more source

Single‐Cell Transcriptome Profiling Reveals Conserved IFNγ‐IL8 Signaling‐Induced Antibacterial Neutrophil States during Bacterial Infection

open access: yesAdvanced Science, EarlyView.
SummaryThis study constructs a single‐cell immune atlas of Nile tilapia across multiple time points during Streptococcus agalactiae infection, revealing dynamic immune cell responses and subtype transitions. It identifies a conserved IFNr‐STAT1‐IL8 axis driving il8+ neutrophils activation and antibacterial function, supported by cross‐species ...
Xue Zhai   +14 more
wiley   +1 more source

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