Results 231 to 240 of about 925,982 (358)

Igfbp2 Downregulation in PVT‐CeA Glutamatergic Circuits Drives Neonatal Anesthesia‐Induced Fear Memory Deficits

open access: yesAdvanced Science, EarlyView.
Repeated neonatal sevoflurane exposure impairs adolescent fear memory through Igfbp2 downregulation in paraventricular thalamus‐central amygdala glutamatergic projections. Restoring Igfbp2 or activating this circuit rescues memory deficits, neuronal excitability, and spine density, identifying a precise molecular target for preventing anesthesia ...
Weiming Zhao   +16 more
wiley   +1 more source

Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype

open access: yesAdvanced Science, EarlyView.
This study demonstrates that biological acidosis, commonly observed in tumors and ischemic conditions, actively promotes the protonation of fatty acids, thereby facilitating the uptake of their neutral forms. Consequently, the preference for lipid metabolism in acid‐exposed cells does not arise from genetic reprogramming that prioritizes lipids as the ...
Sébastien Ibanez   +20 more
wiley   +1 more source

P619: Three years of newborn screening for MPS1 in Ontario: Challenges of screening for the severe end of a disease continuum

open access: yesGenetics in Medicine Open
Melanie Lacaria   +6 more
doaj  

In Vivo Dynamic Coronary Arteries Blood Flow Imaging Based on Multi‐Cycle Phase Clustering Ultrafast Ultrasound

open access: yesAdvanced Science, EarlyView.
This study addresses a critical gap in ultrafast ultrasound cardiovascular flow imaging and introduces a transformative approach, Clustering Singular Value Decomposition (cSVD), which enables dynamic cardiovascular flow imaging throughout full cardiac cycle without motion correction and hyper‐fast imaging strategies.
Hao Yu   +6 more
wiley   +1 more source

P506: Long-term results and challenges of newborn screening for classic homocystinuria in New York State

open access: yesGenetics in Medicine Open
Jing Xiao   +6 more
doaj  

Extremely rare case report of CEBALID syndrome presenting as congenital arthrogryposis. [PDF]

open access: yesBMC Pediatr
Dirani FA   +5 more
europepmc   +1 more source

YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis

open access: yesAdvanced Science, EarlyView.
This study identifies YTHDC1 as a key regulator of postnatal liver development and disease. Hepatocyte‐specific deletion of Ythdc1 impairs hepatocyte maturation, causing liver injury, contributing to nonalcoholic steatohepatitis and hepatocellular carcinoma.
Xinzhi Li   +8 more
wiley   +1 more source

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