Results 201 to 210 of about 256,510 (385)

Brain Imaging Phenotypes Associated with Polygenic Risk for Essential Tremor

open access: yesMovement Disorders, EarlyView.
Abstract Essential tremor (ET) is a common movement disorder with a strong genetic basis. Magnetic resonance imaging (MRI), particularly diffusion‐weighted MRI (dMRI) and T1 MRI, have been used to identify brain abnormalities of ET patients. However, the mechanisms by which genetic risk affects the brain to render individuals vulnerable to ET remain ...
Miranda Medeiros   +14 more
wiley   +1 more source

All‐cause and liver‐related mortality risk factors in excessive drinkers: Analysis of data from the UK biobank

open access: yesAlcoholism: Clinical and Experimental Research, Volume 46, Issue 12, Page 2245-2257, December 2022., 2022
High alcohol intake increases mortality but little is known about risk factors which affect mortality in high‐risk drinkers. We assessed 6640 UKB participants reporting >80g/50g (men/women) alcohol per day. Alcohol use disorders, diagnosis of liver disease, abnormal liver function tests and erythrocyte morphology predicted higher risk of death overall,
John B. Whitfield   +40 more
wiley   +1 more source

Plasma Biomarkers and Disease Prognosis in Mild Cognitive Impairment with Lewy Bodies

open access: yesMovement Disorders, EarlyView.
Abstract Background Little is known about the prognostic value of plasma biomarkers in mild cognitive impairment with Lewy bodies (MCI‐LB). Objectives To investigate the association of four plasma biomarkers with disease progression in MCI. Methods Plasma amyloid‐beta (Aβ)42/40, glial fibrillary acidic protein (GFAP), neurofilament light (NfL), and ...
Paul C. Donaghy   +15 more
wiley   +1 more source

Delirium‐associated medication in people at risk: A systematic update review, meta‐analyses, and GRADE‐profiles

open access: yesActa Psychiatrica Scandinavica, Volume 147, Issue 1, Page 16-42, January 2023., 2023
Abstract Background Drug‐associated delirium is a common but potentially preventable neuropsychiatric syndrome associated with detrimental outcomes. Empirical evidence for delirium‐associated medication is uncertain due to a lack of high‐quality studies.
Michael Reisinger   +4 more
wiley   +1 more source

Treatment Selection and Prioritization for the EJS ACT‐PD MAMS Trial Platform

open access: yesMovement Disorders, EarlyView.
Abstract Background There are currently no disease‐modifying therapies (DMTs) registered for Parkinson's disease (PD). The Edmond J. Safra Accelerating Clinical Trials in Parkinson Disease (EJS ACT‐PD) initiative will expedite clinical assessment of putative DMTs through a multi‐arm multistage (MAMS) trial, testing several treatments against a common ...
Cristina Gonzalez‐Robles   +29 more
wiley   +1 more source

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