Functional impairment in patients with myotonic dystrophy type 1 can be assessed by an ataxia rating scale (SARA) [PDF]
Myotonic dystrophy type 1 (DM1) is not characterised by ataxia per se; however, DM1 and ataxia patients show similar disturbances in movement coordination often experiencing walking and balance difficulties, although caused by different underlying ...
Atalaia, Antonio+6 more
core +2 more sources
c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie+17 more
wiley +1 more source
Effects of Newcastle disease vaccine on the liver and antioxidant enzymes of chicks [PDF]
Newcastle disease is a highly contagious disease of domestic and wild birds result in huge economic losses due to extreme morbidity and mortality. The aim of this paper is to explore the possibility of the harmful impact of Newcastle disease vaccine on ...
N. Mustafa
doaj +1 more source
Grippes aviaires en Afrique. Cibler la vigilance [PDF]
En 2006, la détection du virus de l'influenza (grippe) aviaire H5N1 en Afrique suscite une grande inquiétude : le virus pourrait se propager à l'ensemble du continent, puis être réintroduit en Europe par les oiseaux migrateurs.
Chevalier, Véronique+2 more
core +2 more sources
Long‐Term Evaluation of Givinostat in Duchenne Muscular Dystrophy, and Natural History Comparisons
ABSTRACT Objectives This ongoing, open‐label extension study is evaluating the long‐term safety, tolerability, and efficacy of givinostat, a Class I and II histone deacetylase inhibitor, in patients with Duchenne muscular dystrophy (DMD). Methods The recruited patients completed one of two prior clinical studies (one Phase 2 and one Phase 3 [EPIDYS ...
Craig M. McDonald+74 more
wiley +1 more source
Pengaruh Dosis Vaksin Newcastle Disease Inaktif Pada Itik Betina Terhadap Jumlah Sel Darah Putih Dan Titer Antibodi [PDF]
This study are determines to: 1) the effect of ND vaccine dose to the number of white blood cells produced in the female ducks; 2) the effect of ND vaccine doses to the amount of antibody titers produced in the female ducks.
Pratama, L. (Luthfi)+2 more
core
Cultural Practices Shaping Zoonotic Diseases Surveillance: The Case of Highly Pathogenic Avian Influenza and Thailand Native Chicken Farmers [PDF]
Effectiveness of current passive zoonotic disease surveillance systems is limited by the under-reporting of disease outbreaks in the domestic animal population.
Anderson+31 more
core +4 more sources
Assessing a Mitochondrial Disease Treatment via a Novel Statistical Technique for Accelerometer Data
ABSTRACT Objective Therapeutic development for mitochondrial diseases, rare genetic disorders with pathogenic defects of oxidative phosphorylation, is hindered by unsatisfactory outcome measures. To address this problem, we provide the first clinical application of a novel, bias‐adjusted outcome measure of acceleration across a range of subjects ...
Ian W. McKeague+8 more
wiley +1 more source
Plaque Assay Of Newcastle Disease Virus [PDF]
The Newcastle disease virus (NDV) was isolated from a 3 months-old indigenous chicken (buras or kampung chicken) which showed clinical signs of Newcastle disease (ND).
Sardjono, B. (B)
core
The effect of dietary intake, physical activity and posture on pepsin concentrations detected in the saliva of free-living, healthy individuals [PDF]
Introduction: Diet and lifestyle are believed to be major causes of gastric reflux. The occurrence of reflux is associated with a number of respiratory, oesophageal and airways conditions.
Brownlee, Iain+8 more
core +2 more sources