Results 91 to 100 of about 57,232 (279)

Host Cell Factors Necessary for Influenza A Infection: Meta-Analysis of Genome Wide Studies [PDF]

, 2012
The Influenza A virus belongs to the Orthomyxoviridae family. Influenza virus infection occurs yearly in all countries of the world. It usually kills between 250,000 and 500,000 people and causes severe illness in millions more. Over the last century alone we have seen 3 global influenza pandemics. The great human and financial cost of this disease has
arxiv   +1 more source

Infantile Cerebellar‐Retinal Degeneration Associated With Novel ACO2 Variants: Clinical Features and Insights From a Drosophila Model

Clinical Genetics, EarlyView.
Our Translational Loop integrates patient genetic data with Drosophila models to study disease mechanisms. We identified ACO2 variants in a patient linked to ICRD and show that our animal model mirrors key aspects of the disease. These insights help pinpoint therapeutic targets, advancing research toward treatments for rare genetic disorders.
Edgar Buhl, Suchika Garg, Marie Monaghan, Amy Preston, Marcus Likeman, Julianne Dare, Julie Evans, Lucie S. Taylor, Ian Berry, Kathryn Urankar, Paul G. D. Spry, Cathy Williams, Robert W. Taylor, Charlotte L. Alston, James J. L. Hodge, Anirban Majumdar   +15 more
wiley   +1 more source

Novel insights into the host immune response of chicken Harderian gland tissue during Newcastle disease virus infection and heat treatment

BMC Veterinary Research, 2018
Background Newcastle disease virus, in its most pathogenic form, threatens the livelihood of rural poultry farmers where there is a limited infrastructure and service for vaccinations to prevent outbreaks of the virus.
Perot Saelao, Ying Wang, Rodrigo A. Gallardo, Susan J. Lamont, Jack M. Dekkers, Terra Kelly, Huaijun Zhou   +6 more
doaj   +1 more source

From liver to limb: Exploring the association between fatty liver disease and peripheral artery disease—A systematic review

European Journal of Clinical Investigation, EarlyView.
Abstract Introduction Fatty liver disease, encompassing nonalcoholic fatty liver disease (NAFLD), metabolic dysfunction‐associated fatty liver disease (MAFLD), and the recently redefined metabolic dysfunction‐associated steatotic liver disease (MASLD), is a growing global health concern with significant cardiovascular implications.
Vera Ciornolutchii, Abdulrahman Ismaiel, Jennifer Bogdan, Stefan‐Lucian Popa, Teodora Surdea‐Blaga, Dan L. Dumitrascu   +5 more
wiley   +1 more source

Visible Insights of the Invisible Pandemic: A Scientometric, Altmetric and Topic Trend Analysis [PDF]

arXiv, 2020
The recent SARS-COV-2 virus outbreak has created an unprecedented global health crisis! The disease is showing alarming trends with the number of people getting infected with this disease, new cases and death rate are all highlighting the need to control this disease at the earliest. The strategy now for the governments around the globe is how to limit
arxiv  

Cholesterol dependence of Newcastle Disease Virus entry

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012
Lipid rafts are membrane microdomains enriched in cholesterol, sphingolipids, and glycolipids that have been implicated in many biological processes. Since cholesterol is known to play a key role in the entry of some other viruses, we investigated the role of cholesterol and lipid rafts in the host cell plasma membrane in Newcastle Disease Virus (NDV ...
Isabel Muñoz-Barroso, Lorena Sánchez-Felipe, Juan José Martín, Enrique Villar, Javier Holguera   +4 more
openaire   +3 more sources

Expanding our understanding of synucleinopathies: proteinopathy, proteinopenia, and lipidopathy

The FEBS Journal, EarlyView.
Neurodegeneration is thought to arise due to the disruption of the protein homeostasis. In synucleinopathies, alterations in the levels of functional and aggregated aSyn lead to proteinopenia and proteinopathy, respectively. aSyn and β‐glucocerebrosidase are closely linked to lipid metabolism, impacting organelle function and lipidostasis.
Manuel Flores‐León, Tiago F. Outeiro
wiley   +1 more source

Disease dynamics of Honeybees with Varroa destructor as parasite and virus vector [PDF]

arXiv, 2015
We propose a honeybee-mite-virus model that incorporates (1) parasitic interactions between honeybees and the Varroa mites; (2) five virus transmission terms between honeybees and mites at different stages of Varroa mites: from honeybees to honeybees, from adult honeybees to phoretic mites, from honeybee brood to reproductive mites, from reproductive ...
arxiv  

Advancements in multiple sclerosis

Internal Medicine Journal, EarlyView.
Abstract The global prevalence of multiple sclerosis (MS) is increasing, and early diagnosis and treatment is essential in mitigating disability. While recent therapeutic advancements have significantly reduced relapse rates, the progressive and degenerative aspects of MS continue to pose major challenges.
Turlough Montague, James Drummond, Karl Ng, John Parratt   +3 more
wiley   +1 more source

Modeling the case of early detection of Ebola virus disease [PDF]

arXiv, 2015
The most recent Ebola outbreak in West Africa highlighted critical weaknesses in the medical infrastructure of the affected countries, including effective diagnostics tools, sufficient isolation wards, and enough medical personnel. Here, we develop and analyze a mathematical model to assess the impact of early diagnosis of pre-symptomatic individuals ...
arxiv