Results 131 to 140 of about 152,376 (255)
Reinventing EXARC, a Discussion between Members
EXARC Journal, 2016 At the Annual General Meeting in Leiden (NL) in March 2016, about 25 EXARC members discussed future strategies for EXARC. We intend to collect opinions from members throughout 2016 and present a plan at the Annual General Meeting in 2017.
Roeland P Paardekooper
doaj
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Book Review: Heritage Tourism Destinations by Maria D Alvarez (et al.)
EXARC Journal, 2016 This book is a follow-up from the first Hospitality, Tourism and Heritage International Conference, held in Istanbul, Turkey from the 6th to the-7th November 2014. It is wonderful that these papers were published only two years later. This book’s goal is
Roeland P Paardekooper
doaj
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
The Best Way of Preserving Something is to Educate about it - Educational Centres in South Africa
EXARC Journal, 2016 This article aims to show the kind of issues South- African archaeologists have, working with public archaeology. A past that was segregated earlier should now be shared, but sharing a common past includes alternative perspectives on history and ...
Frauke Sontberg
doaj
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Replication of a Maori Ethnographic Textile Hem Border Pattern
EXARC Journal, 2019 Replication of archaeological and ethnographic Māori textiles, under the direction of customary knowledge and previous practical experience, can provide a more nuanced understanding of the manufacture of taonga (treasures) made from fibre materials.
Lisa McKendry
doaj
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Conference Review: Fibres in Early Textiles, Glasgow 2019
EXARC Journal, 2019 The 16th conference of the Early Textiles Study Group was held at the University of Glasgow, Scotland, from 6th to 7th June, 2019. The theme for the biennial conference, Fibres in Early Textiles from Prehistory to AD 1600, was attended by almost sixty ...
Alistair Dickey
doaj