Results 141 to 150 of about 5,397 (276)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Reinventing EXARC, a Discussion between Members
EXARC Journal, 2016 At the Annual General Meeting in Leiden (NL) in March 2016, about 25 EXARC members discussed future strategies for EXARC. We intend to collect opinions from members throughout 2016 and present a plan at the Annual General Meeting in 2017.
Roeland P Paardekooper
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
In the current era, the learning process needs to be carried out in an integrative manner, especially as technology has developed to such an extent. The learning process is not only carried out technologically, but also contains intellectual, moral and ...
Ishomuddin, Ishomuddin +2 more
core +1 more source
Book Review: Heritage Tourism Destinations by Maria D Alvarez (et al.)
EXARC Journal, 2016 This book is a follow-up from the first Hospitality, Tourism and Heritage International Conference, held in Istanbul, Turkey from the 6th to the-7th November 2014. It is wonderful that these papers were published only two years later. This book’s goal is
Roeland P Paardekooper
doaj
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
У публікації проаналізовано літературну раціональність провідних письменників доби модерну. Творчість українських літераторів вимагає від читача високого рівня підготовки до сприйняття мистецтва, яке протиставлялось масовій культурі. Нова хвиля виразного
Зінов'єва, К. Ф.
core
How to Run a Reenactment - Introduction to Reenactments and Reenactors, Part 1
EXARC Journal, 2019 Reenactments, meaning special events that use outside costumed interpreters, are a great way for sites to engage visitors and host memorable programs that build a following. Planning and executing a reenactment can be a daunting challenge for a site that
Deb Fuller
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source