Results 241 to 250 of about 154,220 (300)

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

Advanced Science, EarlyView.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu, Xue Leng, Jiang Long, Zhengao Liao, Xiaoqin An, Xuezheng Ai, Dan Long, Changqing Li, Bo Huang, Yue Zhou, Shiwu Dong, Chencheng Feng   +11 more
wiley   +1 more source

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Advanced Science, EarlyView.
Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan, Yelian Yan, Yalin Liang, Kanghua Zhong, Zhican Fu, Xiaobo Wang, Chao Liu, Tao Huang, Keliang Wu   +8 more
wiley   +1 more source

Application of guided learning mode supported by MicroCourse online video in nursing safety training of newly recruited nurses

Huli yanjiu, 2017
童静韬, 杨婷, 方汉萍
doaj  

The effect of self-made video assessment on standardized nursing skills training. [PDF]

Front Med (Lausanne)
Li Y, Zhao H, Zhang B.
europepmc   +1 more source

Efficacy and Safety of a Simple Auxiliary Liver Suspension Device in Complex Laparoscopic Hepatectomy: A Multicenter Randomized Clinical Trial

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Purpose To evaluate the efficacy and safety of a novel auxiliary liver suspension device in complex laparoscopic hepatectomy. Methods A total of 253 patients with hepatocellular carcinoma (HCC) undergoing complex laparoscopic hepatectomy at the Third Affiliated Hospital of Naval Medical University, Sichuan Provincial People's Hospital, and ...
Xiao‐Ying Zhu, Zi‐Hui Ma, Lei Guo, Chong Yang, Jie Xue, Xiao‐Lu Lin, Chong‐De Lu, Qin Zheng, Shu‐Qun Cheng, Wei‐Xing Guo   +9 more
wiley   +1 more source

The cortical and subcortical brain regions influence multitasking skills using immersive virtual reality simulation in experienced nurses. [PDF]

Sci Rep
Dos Santos Kawata KH, Ono K, Lem WG, Amari S, Nozawa K, Sasaka M, Kashiwagi K, Oyama H.   +7 more
europepmc   +1 more source

Alcohol Consumption Is a Risk Factor of Surgical Site Infection After Minimally Invasive Surgery: A Secondary Observational Analysis of a Clinical Trial

Annals of Gastroenterological Surgery, EarlyView.
Alcohol consumption was independently associated with Surgical Site Infection in the gastroenterological Minimally Invasive Surgery. Whether preoperative abstinence from alcohol prevents the occurrence of SSI warrants further investigation. ABSTRACT Background Surgical site infection (SSI) is one of the postoperative complications. Risk factors for SSI
Toshiya Akai, Makoto Takeda, Eisuke Booka, Tomohiro Matsumoto, Masayo Takaoka, Mayu Sakata, Yoshifumi Morita, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi   +9 more
wiley   +1 more source

Nurses' Perceptions and Utilization Plans for Applying Companion Robots to Acute Stroke Patient Care: A Delphi Study. [PDF]

Healthc Inform Res
Choo HJ, Lee SM.
europepmc   +1 more source

Visionary Leadership in Cancer Care: An Interview With Professor Timothy J. Eberlein

Annals of Gastroenterological Surgery, EarlyView.
Professor Timothy J. Eberlein and Professor Ken Shirabe, President of the Japanese Society of Gastroenterological Surgery, during their interview discussing the vision, strategic framework, and leadership that shaped the development of the Siteman Cancer Center into a world‐class institution. ABSTRACT This is a short interview with Professor Timothy J.
Ken Shirabe, Koshi Mimori, Masaki Mori, Yuko Kitagawa   +3 more
wiley   +1 more source

Evaluation of a combined tuberculosis case-finding, treatment and prevention strategy in Thailand: protocol for a pragmatic phase IV stepped-wedge cluster-randomised trial, the CaPThai study. [PDF]

Trials
Tovar Sanchez T, Ngamvithayapong-Yanai J, Grint D, Beneteau S, Luangjna S, Ouedraogo S, Lachenal N, Bonnet M, Fielding K, Kamolwat P, Lienhardt C.   +10 more
europepmc   +1 more source