Results 111 to 120 of about 3,855,227 (269)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Between news media reality and lived reality: computational and qualitative analysis of news media's part in civic (dis)engagement

Frontiers in Human Dynamics
This study examines how news media conditions civic (dis)engagement by investigating the news ecosystem as an emotional and informational environment that shapes what citizens feel they can do about their reality.
Sona Manusyan, Ani Grigoryan, Tiruhi Grigoryan, Ani Poghosyan, Nare Paremuzyan, Arin H. Ayanian, Arin H. Ayanian   +6 more
doaj   +1 more source

Mapping of carbon monoxide related death risk in Turkey: a ten-year analysis based on news agency records. [PDF]

BMC Public Health, 2019
Can G, Sayılı U, Aksu Sayman Ö, Kuyumcu ÖF, Yılmaz D, Esen E, Yurtseven E, Erginöz E.   +7 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

A large group of women migrants in front of Australia House, London, England, ca. 1920 [picture] /

, 1920
Title devised by cataloguer.; Inscriptions: London News Agency stamp on verso; "No. 23"--In pencil on verso.; Condition: Yellowing, torn corner and pinholes.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic ...

core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Democracy Dysfunctions and Citizens’ Digital Agency in Highly Contaminated Digital Information Ecosystems

Societies
Social media platforms have been recognized as significant contributors to the dissemination of polarizing content, the spread of disinformation, and the proliferation of far-right populist discourse.
Juan Herrero, Hazal Dilan Erdem, Andrea Torrres, Alberto Urueña   +3 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Homeless Agency: making it home: annual report: 2004.

, 2005
The Homeless Agency is a partnership body that was established as part of the Government strategy on homelessness in May 200 l. It is responsible for the planning and co-ordination of the delivery of quality services to people who are homeless in ...
Homeless Agency
core  

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source