Results 91 to 100 of about 1,804,900 (346)

Public Ethics as a Canadiana “Theologica Publica” [PDF]

open access: yes, 2015
This paper explores how a paradigm of the “public commons” can describe the relationship and contribution of various ‘public’ actors. The paper will explore how we might think differently about ‘public(s)’ and why “public ethics” could serve as a ...
Pfrimmer, David G. A.
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Media Dan Bayang-Bayang Maqasid Al-Mukallaf (Trial By The Press Dan Pemberitaan) Studi Kasus Harian Berita Kota Kendari

open access: yesAl-Izzah, 2018
The article points out the news broadcasted by mass media influenced by maqashid al-mukallaf. It aims to create a harmony delivered to the society. This paper employs the theory of existence which includes several elements; such as frame, stereotype ...
Adi Ashadi L. Diab
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Sensationalism Falling Through the Cracks: Why the Legal Profession Must Broaden Ethical Standards for Legal Commentators [PDF]

open access: yes, 2015
INTRODUCTION Whether it was O.J. Simpson, Casey Anthony, or Scott Peterson, history has shown that Americans love an exciting criminal trial. As a result, in the United States, the coverage and analysis of high-publicity criminal cases is ever-growing ...
LaSala, A. Augustus
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Ethics in research: implications for the higher education

open access: yesRevista Ibero-Americana de Estudos em Educação, 2016
The ethics as a historical movement is the result of combinations, negotiations, disputes of projects, finally integration between entities with differences and diversities.
Antonio Bosco de Lima
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

KEBEBASAN PERS DALAM PERSPEKTIF PERADILAN PIDANA

open access: yesKomunika, 2015
Freedom of the press in the perspective of the criminal justice is the use of the provisions of the Criminal Code; it is not limitation or restraint on freedom of the press, because the provision was only a tool that is used for the testing of ...
Vivi Ariyanti
doaj   +3 more sources

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