Results 101 to 110 of about 71,839 (318)

Ageing: The New Ethical Frontier

open access: yesJournal of Religion, Spirituality & Aging, 2012
The ethics of health care has been dominated by a “crisis” approach—when new issues, such as the refusal of life-sustaining treatments or assisted reproduction, etc., arise we apply tested precepts to new situations. If traditional ethics fail, new ethical thinking is developed.
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

ETIKA JURNALISTIK PERSPEKTIF AL-QUR’AN

open access: yesKomunika, 2015
Today, journalistic world increasingly find its freedom. Its effects can no longer be taken lightly. Therefore, there should be some rules to control and to command the journalists, not to restrict it.
Limmatus Sauda’
doaj  

Perspectives About Breaking Bad News Among Medical Students of Qom University of Medical Sciences

open access: yesHealth, Spirituality and Medical Ethics, 2021
Background and Objectives: Undoubtedly, breaking bad news is one of the most difficult duties of a doctor. Not having this skill and not paying attention to its details can result in poor patient satisfaction, psychological morbidity, and weak clinical ...
Akram Haidari   +3 more
doaj  

"Black chronicle" and ethics in the press in Serbia 100 years ago and today [PDF]

open access: yesCM. Communication and Media
The public's attention in crime news and headlines about accidents and tragedies is not a trend of the new age. News from the so-called "crime chronicle" has been published in the media since the beginning of journalism. Although there is often no public
Cvejić Bojan
doaj   +1 more source

Towards a new ethics for bioculture [PDF]

open access: yesGlobal Bioethics, 2015
The ethics of bioculture deals with moral questions raised by the cultivation and farming of living things. P. W. Taylor believes that they have an inherent worth just like animals and wild plants. Therefore, judgment about how they should be treated cannot be limited to the principle of greater efficiency for the benefit of humans.
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

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