Results 51 to 60 of about 1,963,105 (289)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The Hyperlinked Scandinavian News Ecology. The unequal terms forged by the structural properties of digitalisation [PDF]

, 2018
The article presents a network analysis of 22,861,013 geocoded external hyperlinks, collected from 230 Danish, 220 Norwegian and 208 Swedish news websites in 2016.
Baker C. Edwin, Coddington Mark, Cornia Alessio, Espeland Gard, Gao Yijun, Graves Lucas, Høst Sigurd, Küng Lucy, Lindskow Kasper, Martino Franscesco, Mathisen Birgit R., McLuhan Marshall, Monge Peter R., Newman Nic, Newman Nic, Nielsen Rasmus K., Ohlsson Jonas, Park Hun W., Postman Neil, Rosse James N., Valente Thomas W.   +20 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Changing Channels and Crisscrossing Cultures: A Survey of Latinos on the News Media [PDF]

, 2004
Presents findings from a comprehensive telephone survey that was designed to explore Latinos' preferences for sources of news, their attitudes towards the news media, and the extent to which choices of media affect opinions on key policy ...
Roberto Suro
core  

Urinal or conduit? Institutional information flow between the UK intelligence services and the news media [PDF]

, 2013
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ Sage Publications 2013.Since the 1990s, the Secret Intelligence Service (MI6) and the Security Service (MI5) have developed formal links ...
Lashmar, P
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

WhatsApping terror: how media applied instant messaging to cover Barcelona terrorist attack [PDF]

, 2018
Audiences love live communication (Deuze, 2011), the possibility of reaching news in real time. Previous research focus on the reporting of natural disasters or emergency news like terrorist attacks show that the concept “news now” (Sheller, 2014) is an ...
Palomo-Torres, Maria Bella, Sedano, Jon
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source