Results 61 to 70 of about 6,924 (244)

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

Advanced Science, EarlyView.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Ryan Slusser, Abigail Glezer, Leda Klouda, Melikhan Tanyeri, Anita Saraf   +11 more
wiley   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Understanding News Avoidance in Social Media: A Systematic Literature Review

Religion and Social Communication
In the age of digital media, news avoidance behaviour is continually increasing. This behaviour has brought new challenges for society and democracy. Research on news avoidance has recently experienced a surge, particularly in the wake of the COVID-19 ...
Annapurna Sharma, Mahesh Kumar Meena
doaj   +1 more source

Slow journalism in the “infoxication” era [PDF]

Doxa Comunicación, 2017
Slow journalism appears as a response to the information overload generated by the acceleration of the news production cycle in a digital era marked by the emergence of new operators (social networks, news aggregators).
Samia Benaissa Pedriza
doaj  

Reinforcement Learning with Knowledge Graphs for Personalized News Recommendation [PDF]

ITM Web of Conferences
In recent years, the rapid growth of online media and personalized news recommendations have become essential for reducing information overload and improving user engagement.
Pralhadrao Magar Shyamsundar, Vinodh Kumar Metti, B M Manjula, Gudala Leeladhar   +3 more
doaj   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

News Recommendation With Word-Related Joint Topic Prediction

IEEE Access
As the problem of information overload becomes more severe, it has become increasingly difficult for users to browse news that they are interested in. News recommendation is an effective method to alleviate this problem.
Xiuze Pu, Jincheng Zhang, Xi Chen, Yingjing Qian, Renmin Zhang   +4 more
doaj   +1 more source

A Multimodal Magnetically Driven Soft Robot With Integrated Actuation‐Sensing Based on Photothermal Reprogramming Technology

Advanced Science, EarlyView.
This work reports a thermally safe, photothermally reprogrammable magnetic soft robot with its reprogramming temperature tuned to ∼39.5°C for biocompatibility. It achieves multimodal locomotion (max speed of 1.8 BL/s) and integrates liquid‐metal capacitive sensing to monitor self‐motion and detect environmental changes in simulated gastric environments,
Liu Yang, Yuliao Dong, Kangning Li, Cheng Jing, Ben Wang, Lin Xu   +5 more
wiley   +1 more source

BlogNewsRank: Finding and Ranking Frequent News Topics Using Social Media Factors

JOIV: International Journal on Informatics Visualization, 2018
In early days, mass media sources such as news media used to inform us about daily events. Now a days, social media services such as Twitter huge amount of user-generated data, which has a great potential to contain informative news-related content.
Harshitha H, Mohammed Rafi
doaj   +1 more source