Results 71 to 80 of about 3,662,984 (294)
Constitution and Bylaws of The Pioneers of Newport News
This is the image of a small booklet containing the constitution and bylaws of the Pioneers Club of Newport News, Virginia. The Pioneers Club was an association of men who had lived a long period of time in Newport News, Virginia and had made ...
The Pioneers of Newport News
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Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
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Modeling and Optimization of News-Stock Price Correlation Based on Topic Influence Selection
This study examines the evolving relationship between news topics and stock prices, offering a quantitative analysis of how thematic news coverage influences market volatility.
Huaxi Liu +4 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The microbiome in human skin aging
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Efficient Tracking of News Topics Based on Chronological Semantic Structures in a Large-Scale News Video Archive [PDF]
Recent advance in digital storage technology has enabled us to archive a large volume of video data. Thanks to this trend, we have archived more than 1,800 hours of video data from a daily Japanese news show in the last ten years.
MURASE, Hiroshi +6 more
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This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Winter Park Topics News Article About Mrs. Gordon Jones Saturday April 17, 1937
A news article in Winter Park Topics about Mrs. Gordon Jones who became the new president of the Garden Club.
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