Results 71 to 80 of about 3,611,094 (240)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

News Consumption and Trust in Online and Social Media: An In-depth Qualitative Study of Young Adults in Austria

open access: yesInternational Journal of Communication, 2020
Current surveys such as the Reuters Digital News Report 2018 show that trust in the media is at an all-time low in Austria. Among those between 18 and 24 years of age, more people distrust news than trust it.
Uta Russmann, Andreas Hess
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

The Algorithmic Public Sphere: AI-Generated News Site as a Conduit to Social Capital

open access: yesHuman-Machine Communication Journal
A growing body of scholarship on AI-generated news has examined its impact on various outcomes. However, less attention has been paid to the actual implementation of AI-generated news sites and their effectiveness on civic consequences.
Seungahn Nah   +6 more
doaj   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Trust in Scientists and Conspiracy Beliefs Predict Online Misinformation Susceptibility and Fake News Detection: A Cross-Sectional Study in Greece

open access: yesJournalism and Media
Online misinformation has grown significantly with the widespread use of the internet and the ease of sharing content through social media, often without rigorous fact-checking or scientific validation. In this context, we examined the effect of trust in
Aglaia Katsiroumpa   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

News Avoidance and Media Trust: Exploring Intentional Public Disengagement in Egypt’s Media System

open access: yesJournalism and Media
This study examines news avoidance behaviors in Egypt’s media system, addressing a significant gap in understanding how audiences disengage from news content in non-Western contexts. Using a mixed-methods approach combining focus groups (n = 16), surveys
Ahmed Taher, Farah Ismail
doaj   +1 more source

Media Use and Political Trust in Kenya: Media Malaise or Virtuous Circle?

open access: yesInternational Journal of Communication, 2023
Although there is a large corpus of research on the relationship between media use and political trust, this scholarship mainly comes from the experiences of audiences in the West and Confucian Asia.
Gilbert Kipkoech
doaj  

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