Results 11 to 20 of about 65,115 (183)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Identifying pathways of exposure to highway pollutants in great crested newt (Triturus cristatus) road mitigation tunnels: Exposure pathways of highway pollutants to Triturus cristatus [PDF]

, 2017
Road mitigation tunnels are increasingly deployed for amphibians but very little is known about chemical pollution in such schemes. We assessed pollution pressures associated with road runoff at a major great crested newt mitigation scheme in England ...
Mayes, William M., Petrovan, Silviu O., White, Katie J.   +2 more
core   +1 more source

The Legislation for Providing Animal Access in Australian Residential Aged Care: It's Not a Zoo

Australian Journal of Social Issues, EarlyView.
ABSTRACT Providing meaningful animal contact to residential aged care facility (RACF) residents is problematic due to a lack of animal policies and National Guidelines. This paper examines how Australian Legislation could influence access to animal contact in RACFs and aims to answer the question, ‘Could current Legislation facilitate the development ...
Wendy Newton, Tania Signal, Jenni A. Judd   +2 more
wiley   +1 more source

Choosing the best of both worlds [PDF]

, 2011
The great crested newt (Triturus cristatus) is dependent on two environments for its survival: the aquatic habitat necessary for breeding and development, and the terrestrial habitat required for post-breeding and juvenile activities. For a population to
Gustafson, Daniel
core  

Realising Aboriginal Community Controlled Approaches to Child Reunification

Australian Journal of Social Issues, EarlyView.
ABSTRACT Reunification rates for Aboriginal and Torres Strait Islander children in out‐of‐home care (OOHC) in Australia are critically low, even though reunification is the preferred permanency outcome for children following removal, and despite a range of mechanisms and strategies ostensibly to support effective reunification. To better understand the
B. J. Newton, Paul Gray, Kathleen Falster, Ilan Katz, Kyllie Cripps   +4 more
wiley   +1 more source

First observation of facultative paedomorphosis in the Danube crested newt (Triturus dobrogicus Kiritzescu, 1903) and the occurrence of facultative paedomorphosis in two newt species from soda pans of the Danube-Tisza Interfluve (Kiskunság National Park, Hungary) [PDF]

, 2013
The first observation of paedomorphosis in Triturus dobrogicus and the occurrence of facultative paedomorphosis in two newt species (T.dobrogicus and Lissotriton vulgaris) from soda pans of the Danube- Tisza Interfluve, Hungary are reported in this ...
Cozma, Nastasia Julianna, Mester, Béla, Puky, Miklós   +2 more
core  

Beyond mammals: the evolution of chewing and other forms of oropharyngeal food processing in vertebrates

Biological Reviews, EarlyView.
ABSTRACT Oropharyngeal food processing exhibits a remarkable diversity among vertebrates, reflecting the evolution of specialised ‘processing centres’ associated with the mandibular, hyoid, and branchial arches. Although studies have detailed various food‐processing strategies and mechanisms across vertebrates, a coherent and comprehensive terminology ...
Daniel Schwarz, Maja Mielke, Stephan Handschuh, Anthony Herrel, Patrick Lemell, Léa Da Cunha, Nicolai Konow   +6 more
wiley   +1 more source

Testing threats in repeated games [PDF]

, 2005
Under most game-theoretic solution concepts, equilibrium beliefs are justified by off-equilibrium events. I propose an equilibrium concept for infinitely repeated games, called "Nash Equilibrium with Tests" (NEWT), according to which players can only ...
Spiegler, R
core  

Investigating diet as the source of tetrodotoxin in Pleurobranchaea maculata [PDF]

, 2014
The origin of tetrodotoxin (TTX) is highly debated; researchers have postulated either an endogenous or exogenous source with the host accumulating TTX symbiotically or via food chain transmission.
Adamson, Janet E., Cary, S. Craig, Khor, Serena, McNabb, Paul, Salvitti, Lauren R., Taylor, David I., Wood, Susanna A.   +6 more
core   +2 more sources