Results 51 to 60 of about 1,264,492 (331)

A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma

Cell Death Discovery, 2021
Malignant pleural mesothelioma (MPM) is an aggressive cancer with treatment limited to Cisplatin and Pemetrexed chemotherapy. Recently, we showed that drugs targeting the BCL-2-regulated apoptosis pathway could kill MPM cell lines in vitro, and control ...
Surein Arulananda, Megan O’Brien, Marco Evangelista, Laura J. Jenkins, Ashleigh R. Poh, Marzena Walkiewicz, Trishe Leong, John M. Mariadason, Jonathan Cebon, Srividya B. Balachander, Justin R. Cidado, Erinna F. Lee, Thomas John, Walter D. Fairlie   +13 more
doaj   +1 more source

Artifact‐Minimizing Ultrathin Transparent Electrodes Fabricated via iCVD for In Vivo Optogenetic Stimulation and Neural Signal Monitoring of Primary Visual Cortex

Advanced Functional Materials, EarlyView.
We present ultrathin flexible transparent electrodes through iCVD‐enabled molecular control of 10 nm gold films on poly(dimethylaminomethylstyrene). In vivo validation demonstrated photoelectric artifact reduction vs. opaque electrodes and preservation of natural neural dynamics.
Tae Jin Mun, Minju Kim, Chaesung Kim, Yunyoung Choi, In‐Yeop Baek, Younghak Cho, Gyeongyong Lee, Yerim Jang, Min‐Ho Nam, Wonryung Lee, Maesoon Im, Hyejeong Seong   +11 more
wiley   +1 more source

¿POR QUÉ LEIBNIZ REQUIERE DEL TIEMPO ABSOLUTO?

Ideas y Valores, 2007
En este ensayo pongo en contraposición dos doctrinas conspicuamente leibnicianas: la doctrina del tiempo relacional e ideal, y la doctrina de la armonía preestablecida.
NICOLÁS VAUGHAN C
doaj  

Forest restoration increases isolated wetland hydroperiod: a long‐term case study

Ecosphere, 2021
Geographically isolated wetlands (GIWs) are well known as “hotspots” for biodiversity and other ecosystem services, making their value on landscapes disproportionate to the area they occupy.
S. W. Golladay, B. A. Clayton, S. T. Brantley, C. R. Smith, J. Qi, D. W. Hicks   +5 more
doaj   +1 more source

The relative and absolute timing accuracy of the EPIC-pn camera on XMM-Newton, from X-ray pulsations of the Crab and other pulsars

, 2012
Reliable timing calibration is essential for the accurate comparison of XMM-Newton light curves with those from other observatories, to ultimately use them to derive precise physical quantities.
A. Ibarra, A. Martin-Carrillo, A. Wellbrock, Abdo, Arons, Becker, Cheng, Cheng, Crawford, Cusumano, De Luca, de Plaa, den Herder, Dodson, E. Kendziorra, Freyberg, G. Schönherr, Gabriel, Harding, Harding, Helfand, I. Caballero, Jansen, Johnston, K. Mukerjee, Kirsch, Kirsch, Kuiper, Kuiper, Livingstone, Livingstone, Lyne, M. G. F. Kirsch, M. Guainazzi, M. J. Freyberg, M. Stuhlinger, Manchester, Marshall, Marshall, Mason, Massaro, Middleditch, Mineo, Moffat, Molkov, Mori, Mori, N. Webb, Oosterbroek, Pravdo, Pravdo, R. D. Saxton, R. Staubert, Rankin, Romani, Rots, Rots, S. Suchy, Seward, Seward, Shibanov, Staelin, Strüder, Tennant, Turner, U. Lammers, Vaghan, Webb, Willingale, Wilson-Hodge, Zhang, Zhang, Ögelman   +72 more
core   +1 more source

Photon Avalanching Nanoparticles: The Next Generation of Upconverting Nanomaterials?

Advanced Functional Materials, EarlyView.
This Perspective outlines the mechanistic foundations that enable photon‐avalanche (PA) behavior in lanthanide nanomaterials and contrasts them with emerging application spaces and forward‐looking design strategies. By bridging threshold engineering, energy‐transfer dynamics, and materials engineering, we provide a coherent roadmap for advancing the ...
Kimoon Lee, Yunseo Kim, Hyeong‐ku Jo, Dongjoon Yoon, Byeonghyeok Im, WonJeong Yu, Eui‐Rim On, Changhwan Lee   +7 more
wiley   +1 more source

Republication of “Stress Fractures of the Foot and Ankle in Athletes”

Foot & Ankle Orthopaedics, 2023
Stress fractures of the foot and ankle are common injuries in athletes. Management differs considerably based on fracture location and predisposing factors. Repetitive loading of the foot and ankle in athletes should result in physiologic bone remodeling
Philip B. Kaiser MD, Daniel Guss MD, MBA, Christopher W. DiGiovanni MD   +2 more
doaj   +1 more source

Effective universality in quantum gravity

, 2018
We investigate the asymptotic safety scenario for a scalar-gravity system. This system contains two avatars of the dynamical Newton coupling, a gravitational self-coupling and a scalar-graviton coupling.
Eichhorn, Astrid, Labus, Peter, Pawlowski, Jan M., Reichert, Manuel   +3 more
core   +1 more source

Halide‐Dependent Photoluminescence and Heavy‐Atom Effects in Low‐Melting Organic–Inorganic Manganese Halides

Advanced Functional Materials, EarlyView.
Two pyridinium‐based ionic liquid templated hybrid manganese halides, (C4Py)2[MnCl4] and (C4Py)2[MnBr4], display similar bulk structures but show significantly different photoluminescence behaviors due to the bromine heavy‐atom effect. Their stable local Mn environments remain intact even in the molten state, allowing applications such as luminescence ...
Biswajit Bhattacharyya, Christian Balischewski, Jiyong Kim, Tiago Duarte, Lianshe Fu, Rute A.S. Ferreira, Alkit Beqiraj, Iuliia Mikulska, Diego Gianolio, Eric Sperlich, Felix Stete, Wouter Koopman, Christina Günter, Katlen Brennenstuhl, Daniel Van Opdenbosch, Cordt Zollfrank, Armin Wedel, Beth J. Murray, Małgorzata Swadźba‐Kwaśny, Tillmann Klamroth, Michael U. Kumke, Verónica de Zea Bermudez, Andreas Taubert   +22 more
wiley   +1 more source

A teoria da luz de Newton nos textos de Young

Revista Brasileira de Ensino de Física
A concepção de Newton sobre a luz tem sido alvo de controvérsia. Alguns autores consideram sua teoria puramente corpuscular; outros, infiuenciados pelos textos de Young, defendem que ela seria uma combinação de elementos corpusculares e ondulatórios.
Fabio W.O. da Silva
doaj   +1 more source