Results 151 to 160 of about 98,087 (266)

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Elucidation of DPP-4 involvement in systemic distribution and renal reabsorption of linagliptin by PBPK modeling with a cluster Gauss-Newton method. [PDF]

Clin Transl Sci
Nakamura R, Yoshikado T, Aoki Y, Sugiyama Y, Chiba K.   +4 more
europepmc   +1 more source

Data and performance of an active-set truncated Newton method with non-monotone line search for bound-constrained optimization. [PDF]

Data Brief, 2018
Cristofari A, De Santis M, Lucidi S, Rinaldi F.   +3 more
europepmc   +1 more source

A local Minimax-Newton method for finding . . .

, 2008
In this paper, a local minimax-Newton method is developed to solve for multiple saddle points. The local minimax method [15] is used to locate an initial guess and a version of the generalized Newton method is used to speed up convergence. When a problem
Jianxin Zhou, Zhi-qiang Wang
core  

Comparison of modelling approaches for liquid fluidized beds

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract This study presents a comparison of three promising numerical models for the detailed simulation of liquid–solid fluidized bed. These models differ in their treatment of the solid phase, ranging from treating each particle individually to treating the collection of particles as a continuum.
Andreu Bernad‐Serra, Furkhat Khamitov, Olli H. Sorvari, Ville Alopaeus   +3 more
wiley   +1 more source

Stochastic Gauss-Newton method for estimating absorption and scattering in optical tomography with the Monte Carlo method for light transport. [PDF]

Biomed Opt Express
Kangasniemi J, Mozumder M, Pulkkinen A, Tarvainen T.   +3 more
europepmc   +1 more source

A partial envelope approach for modelling multivariate spatial‐temporal data

Canadian Journal of Statistics, EarlyView.
Abstract In the new era of big data, modelling multivariate spatial‐temporal data is a challenging task due to both the high dimensionality of the features and complex associations among the responses across different locations and time points.
Reisa Widjaja, Wenbo Wu, Victor De Oliveira, Keying Ye   +3 more
wiley   +1 more source

Gradient regularization of Newton method with Bregman distances. [PDF]

Math Program
Doikov N, Nesterov Y.
europepmc   +1 more source

Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane‐Fly Spermatocytes

Cytoskeleton, EarlyView.
ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos, Maral Janan, Martina Krüger, Aavo‐Valdur Mikelsaar, Arthur Forer, Rose Sheykhani   +5 more
wiley   +1 more source

Cluster Gauss-Newton method for a quick approximation of profile likelihood: With application to physiologically-based pharmacokinetic models. [PDF]

CPT Pharmacometrics Syst Pharmacol
Aoki Y, Sugiyama Y.
europepmc   +1 more source