Results 161 to 170 of about 98,087 (266)

Clinical Validation of a QSP Model for ISB 2001, a Trispecific T Cell Engager to Support Optimal FIH Study Design in RRMM Patients

Clinical Pharmacology &Therapeutics, EarlyView.
ISB 2001 is a trispecific antibody that binds to two tumor‐associated antigens (TAA), CD38 and BCMA, and crosslinks to CD3 on T cells resulting in T cell‐mediated cytotoxicity of tumor cells expressing these TAAs. ISB 2001 is currently being tested in relapsed and/or refractory multiple myeloma (RRMM) patients in the first‐in‐human (FIH) TRIgnite‐1 ...
Vinu Chandralayam Ayyappa Menon, Tomomi Matsuura, Beata Holkova, Girish S. Gudi, Adam Drake, Maria Pihlgren, Piet H. van der Graaf, Sunitha GN, Andrew Garton, Mario Perro, Cyril Konto, Lida Pacaud   +11 more
wiley   +1 more source

Quenching the Hubbard Model: Comparison of Nonequilibrium Green's Function Methods

Contributions to Plasma Physics, EarlyView.
ABSTRACT We benchmark nonequilibrium Green's function (NEGF) approaches for interaction quenches in the half‐filled Fermi–Hubbard model in one and two dimensions. We compare fully self‐consistent two‐time Kadanoff–Baym equations (KBE), the generalized Kadanoff–Baym ansatz (GKBA), and the recently developed NEGF‐based quantum fluctuations approach (NEGF‐
Jan‐Philip Joost, Christopher Makait, Alexander Osterkorn, Erik Schroedter   +3 more
wiley   +1 more source

Ultrafast Transitions in X‐Ray Irradiated Solids

Contributions to Plasma Physics, EarlyView.
ABSTRACT In this review, we present current developments on modeling ultrafast transitions in solids triggered by intense, atto‐ to femtosecond pulses from X‐ray free electron lasers. This specific irradiation regime requires dedicated simulation tools based on theoretical and computational methods, involving the elements of classical and quantum ...
Sebastião Antunes, Konrad J. Kapcia, Vladimir Lipp, Beata Ziaja   +3 more
wiley   +1 more source

Resonance‐induced restoration of rock permeability degraded by heavy components of crude oil

Deep Underground Science and Engineering, EarlyView.
Resonance‐induced changes occur in filtration properties of sedimentary rocks in crude paraffin oil flow under acoustic vibrations. Experimental data on (a) pressure drop; (b) permeability; (c) pressure at the rock inlet; and (d) pressure at the rock outlet are presented.
Evgenii Riabokon, Qian Yin, Mikhail Guzev, Mikhail Turbakov, Evgenii Kozhevnikov, Nadezhda Riabokon, Ivan Panteleev   +6 more
wiley   +1 more source

Creep properties and constitutive model of diabase in deep water conveyance tunnels

Deep Underground Science and Engineering, EarlyView.
The axial and lateral creep characteristics of diabase were analyzed based on compression creep tests. The nonlinear viscoelastic‐plastic model capable of describing the whole creep process was established based on the fractional derivative and damage theories.
Zhigang Tao, Pengxiao Guan, Xiaojie Yang, Keyuan Liu, Mingjiu Cai, Hong Yang   +5 more
wiley   +1 more source

On local convergence analysis of inexact Newton method for singular systems of equations under majorant condition. [PDF]

ScientificWorldJournal, 2014
Zhou F.
europepmc   +1 more source

Nonsilting transport characteristics of coal slurry in a deep underground fluidization conveying pipeline under the action of a guide vane swirler

Deep Underground Science and Engineering, EarlyView.
Aiming at the scientific frontiers of in situ fluidized mining of deep resources, a deep coal fluidized pipeline lifting system based on hydraulic conveying has been proposed. To solve the issue of particle sedimentation of large particles in horizontal connection sections, a solution involving the installation of guide vane‐type swirlers in the ...
Jiusheng Bao, Shaodi Zhao, Yan Yin, Zhongbin Wang, Shuai Liu, Shirong Ge   +5 more
wiley   +1 more source

Review and prospects of shear test of bolted rock joints

Deep Underground Science and Engineering, EarlyView.
The laboratory shear test equipment, test method, and numerical simulation of bolted rock joints were summarized. The shortcomings and limitations of the current research were analyzed, and the research prospects were proposed. Abstract Rock bolting is a critical approach in geotechnical engineering for supporting weak rocks.
Shulin Ren, Fan Yang, Manchao He, Yong Yuan, Zhigang Tao   +4 more
wiley   +1 more source

Constraint-based perturbation analysis with cluster Newton method: a case study of personalized parameter estimations with irinotecan whole-body physiologically based pharmacokinetic model. [PDF]

BMC Syst Biol, 2017
Asami S, Kiga D, Konagaya A.
europepmc   +1 more source

Motion planning and control of an installation robot for attitude adjustment of arc parts in underground shield tunneling

Deep Underground Science and Engineering, EarlyView.
Inspired by spiders, the multilegged walk‐through assembling robot for arc parts achieves high‐precision synchronous control under heavy loads through dual‐layer hydraulic pose dynamics modeling and hierarchical pressure optimization, significantly enhancing shield tunneling assembly efficiency and precision.
Quan Xiao, Guofei Xiang, Liang Liao, Lai Wei, Hongli Wang, Songyi Dian   +5 more
wiley   +1 more source