Results 131 to 140 of about 1,460,723 (393)
Frontiers in Genetics, 2019 Modification mapping from cDNA data has become a tremendously important approach in epitranscriptomics. So-called reverse transcription signatures in cDNA contain information on the position and nature of their causative RNA modifications. Data mining of,
Lukas Schmidt +14 more
doaj +1 more source
Identities for Tribonacci-related sequences [PDF]
arXiv, 2002 We establish some identities relating two sequences that are, as explained, related to the Tribonacci sequence. One of these sequences bears the same resemblance to the Tribonacci sequence as the Lucas sequence does to the Fibonacci sequence. Defining a matrix that we call Tribomatrix, which extends the Fibonacci matrix, we see that the other sequence ...
arxiv
ART: a next-generation sequencing read simulator
Bioinform., 2012 UNLABELLED ART is a set of simulation tools that generate synthetic next-generation sequencing reads. This functionality is essential for testing and benchmarking tools for next-generation sequencing data analysis including read alignment, de novo ...
Weichun Huang +3 more
semanticscholar +1 more source
Evolution of genome sequencing techniques [PDF]
, 2016 The quality and the speed for genome sequencing has advanced at the same time that technology boundaries are stretched. This advancement has been divided so far in three generations.
Goebel Vázquez, Cristina +1 more
core
Forensic SNP genotyping using nanopore MinION sequencing [PDF]
, 2017 One of the latest developments in next generation sequencing is the Oxford Nanopore Technologies' (ONT) MinION nanopore sequencer. We studied the applicability of this system to perform forensic genotyping of the forensic female DNA standard 9947 A using
Cornelis, Senne +4 more
core +2 more sources
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Next-generation sequencing in liquid biopsy: cancer screening and early detection
Human Genomics, 2019 In recent years, the rapid development of next-generation sequencing (NGS) technologies has led to a significant reduction in sequencing cost with improved accuracy.
Ming Chen, Hongyu Zhao
semanticscholar +1 more source
Bioinformatics and Computational Tools for Next-Generation Sequencing Analysis in Clinical Genetics
Journal of Clinical Medicine, 2020 Clinical genetics has an important role in the healthcare system to provide a definitive diagnosis for many rare syndromes. It also can have an influence over genetics prevention, disease prognosis and assisting the selection of the best options of care ...
R. Pereira, J. Oliveira, M. Sousa
semanticscholar +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source