Results 111 to 120 of about 614,915 (309)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Symposium NGS 2016 - ‘Next generation sequencing’ technology in routine analysis in Belgian healthcare system (EN)

, 2016
‘Next generation sequencing’ technology in routine analysis in Belgian healthcare system.
M. Van den Bulcke
core  

Graphical Workflow System for Modification Calling by Machine Learning of Reverse Transcription Signatures

Frontiers in Genetics, 2019
Modification mapping from cDNA data has become a tremendously important approach in epitranscriptomics. So-called reverse transcription signatures in cDNA contain information on the position and nature of their causative RNA modifications. Data mining of,
Lukas Schmidt, Stephan Werner, Thomas Kemmer, Stefan Niebler, Marco Kristen, Lilia Ayadi, Lilia Ayadi, Patrick Johe, Virginie Marchand, Tanja Schirmeister, Yuri Motorin, Yuri Motorin, Andreas Hildebrandt, Bertil Schmidt, Mark Helm   +14 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Assessment of Mapping and SNP-Detection Algorithms for Next-Generation Sequencing Data in Cancer Genomics

, 2013
The rapid development of next-generation sequencing (NGS) technology provides a new chance to extend the scale and resolution of genomic research. How to efficiently map millions of short reads to the reference genome and how to make accurate variant ...
Wang, JJ, Junwen Wang, Wang, W, Weixin Wang, Xu, F, Feng Xu   +5 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

ParMap, an Algorithm for the Identification of Complex Genomic Variations in Nextgen Sequencing Data

, 2010
Next-generation sequencing produces high-throughput data, albeit with greater error and shorter reads than traditional Sanger sequencing methods. This complicates the detection of genomic variations, especially, small insertions and deletions.
Raul Rabadan, Adolfo A. Ferrando, Teresa Palomero, Hossein Khiabanian, Pieter Van Vlierberghe   +4 more
core  

Error correction and diversity analysis of population mixtures determined by NGS [PDF]

, 2014
The impetus for this work was the need to analyse nucleotide diversity in a viral mix taken from honeybees; the methods are illustrated using honeybee viral samples. The paper has two findings. First, a method for correction of next generation sequencing
David J Evans, Graham R Wood, Nigel J. Burroughs, Wood, Graham, Burroughs, Nigel J., Graham R. Wood, David J. Evans, Nigel Burroughs, Ryabov, Eugene V., Wood, Graham R., Burroughs, Nigel John, Evans, David J., Eugene V. Ryabov, Eugene V Ryabov   +13 more
core   +1 more source

Deciphering the Natural Reassortment Dynamics of Infectious Bursal Disease Virus, Isolated from Field Outbreaks in Southern India, Through Complete Genome Sequencing

Pathogens
The present study was carried out to analyze the complete genome sequences of infectious bursal disease virus (IBDV) isolates obtained from field outbreaks in the southern regions of India.
Raja Paramasivam, Megan Justice, Tuticorin Maragatham Alagesan Senthilkumar, Manoharan Parthiban, Ardhanary Thangavelu, Angappan Mangala Gowri, Ramasamy Bharathi, Hong Hwang, Jerry Malayer, Samuel Pushparaj   +9 more
doaj   +1 more source

Next-generation Sequencing and Norovirus [PDF]

Future Virology, 2016
Cotten, Matthew, Koopmans, Marion
openaire   +3 more sources