Results 101 to 110 of about 5,736,241 (346)

Application of metagenomic next-generation sequencing in the diagnosis of infectious diseases

Frontiers in Cellular and Infection Microbiology
Metagenomic next-generation sequencing (mNGS) is a transformative approach in the diagnosis of infectious diseases, utilizing unbiased high-throughput sequencing to directly detect and characterize microbial genomes from clinical samples.
Yu Zhao, Wenhui Zhang, Xin Zhang
semanticscholar   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Application of next-generation sequencing to identify different pathogens

Frontiers in Microbiology
Early and precise detection and identification of various pathogens are essential for epidemiological monitoring, disease management, and reducing the prevalence of clinical infectious diseases.
A. Nafea, Yu-Er Wang, Duan-Yang Wang, Ahmed M. Salama, Manal A. Aziz, Shan Xu, Yigang Tong   +6 more
semanticscholar   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

ParMap, an Algorithm for the Identification of Complex Genomic Variations in Nextgen Sequencing Data [PDF]

, 2010
Next-generation sequencing produces high-throughput data, albeit with greater error and shorter reads than traditional Sanger sequencing methods. This complicates the detection of genomic variations, especially, small insertions and deletions.
Raul Rabadan, Adolfo A. Ferrando, Teresa Palomero, Hossein Khiabanian, Pieter Van Vlierberghe   +4 more
core  

Next Generation Sequencing as a Tool for Noninvasive Prenatal Tests

, 2016
Prenatal diagnosis involves all available procedures to determine the health status of a fetus or embryo before birth, including screening for genetically based diseases. Two mechanisms cause genetic or gene-related diseases.
Cogulu O., Ozgur Cogulu
core   +1 more source

Dysregulated NK-cell gene expression defines the enduring symptoms of long COVID-19

Frontiers in Immunology
IntroductionLong-term COVID-19 syndrome (LTCS) or “long COVID” is a debilitating post-viral condition affecting approximately 2%–8% of individuals after SARS-CoV-2 infection. It manifests typically ≥3 months post-infection with symptoms persisting for at
Urvi Ray, Urvi Ray, Antje Schulze Selting, Antje Schulze Selting, Roshan Priyarangana Perera, Zhiqi Yang, Vladislav Lysenkov, Vladislav Lysenkov, Siri Göpel, Siri Göpel, Michael Bitzer, Madhuri S. Salker, Madhuri S. Salker, Madhuri S. Salker, Madhuri S. Salker, Stephan Ossowski, Stephan Ossowski, Olaf Riess, Olaf Riess, Nicolas Casadei, Nicolas Casadei, Yogesh Singh, Yogesh Singh, Yogesh Singh   +23 more
doaj   +1 more source

Microbiological Diagnostic Performance of Metagenomic Next-generation Sequencing When Applied to Clinical Practice.

Clinical Infectious Diseases, 2018
Background Metagenomic next-generation sequencing (mNGS) was suggested to potentially replace traditional microbiological methodology because of its comprehensiveness.
Q. Miao, Yuyan Ma, Qingqing Wang, Jue Pan, Yao Zhang, Wenting Jin, Yumeng Yao, Yi Su, Yingnan Huang, Mengran Wang, Bing-Yu Li, Huayin Li, Chunmei Zhou, Chun Li, M. Ye, Xiao-Lin Xu, Yongjun Li, Bijie Hu   +17 more
semanticscholar   +1 more source

Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant

Pediatric Blood &Cancer, EarlyView.
Matthew R. Schuelke, Julia Wang, Haley Newman, Evelyn Kurpiewski, Anne Reilly, Susan R. Rheingold, Gerald Wertheim, Moe Takeda, Daniel J. Zheng, Kaitlin Devine   +9 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source