Results 81 to 90 of about 1,096,418 (305)

A Population‐Based Study on Childhood Aplastic Anemia—Incidence, Outcomes, and Health‐Related Quality of Life

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Childhood aplastic anemia (AA) is a rare disease, and both the disease itself and its treatment cause significant morbidity. We aimed to determine the contemporary incidence of childhood AA in Finland, to compare the clinical characteristics of AA against inherited bone marrow failure syndromes (IBMFS) and refractory cytopenia of ...
Lauri‐Matti Kulmala, Riitta Niinimäki, Tytti Pokka, Anu Huurre, Liisa Järvelä, Sauli Palmu, Tuuli Pöyhönen, Pauliina Utriainen, Henri Aarnivala   +8 more
wiley   +1 more source

Participating in Next Generation Sequencing [PDF]

Genetic Testing and Molecular Biomarkers, 2015
On February 20, 2015, as part of the Precision Medicine Initiative, announced by President Obama, the Food and Drug Administration (FDA) held a meeting at the National Institutes of Health (NIH) all day. The meeting was titled “Optimizing FDA's Regulatory Oversight of Next Generation Sequencing Diagnostic Tests” (Food and Drug Administration, 2015 ...
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Application of metagenomic next-generation sequencing in the diagnosis of infectious diseases

Frontiers in Cellular and Infection Microbiology
Metagenomic next-generation sequencing (mNGS) is a transformative approach in the diagnosis of infectious diseases, utilizing unbiased high-throughput sequencing to directly detect and characterize microbial genomes from clinical samples.
Yu Zhao, Wenhui Zhang, Xin Zhang
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Putative mRNA Biomarkers for the Eradication of Infection in an Equine Experimental Model of Septic Arthritis

Veterinary Sciences
Septic arthritis (SA) in horses has long-term health implications. The success of its resolution hinges on the implementation of early, aggressive treatment, which is often sustained over a prolonged period. Common diagnostic methods do not allow for the
Roman V. Koziy, José L. Bracamonte, George S. Katselis, Daniel Udenze, Shahina Hayat, S. Austin Hammond, Elemir Simko   +6 more
doaj   +1 more source

Application of next-generation sequencing to identify different pathogens

Frontiers in Microbiology
Early and precise detection and identification of various pathogens are essential for epidemiological monitoring, disease management, and reducing the prevalence of clinical infectious diseases.
A. Nafea, Yuer Wang, Duanyang Wang, Ahmed M. Salama, Manal A. Aziz, Shan Xu, Yigang Tong   +6 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Dysregulated NK-cell gene expression defines the enduring symptoms of long COVID-19

Frontiers in Immunology
IntroductionLong-term COVID-19 syndrome (LTCS) or “long COVID” is a debilitating post-viral condition affecting approximately 2%–8% of individuals after SARS-CoV-2 infection. It manifests typically ≥3 months post-infection with symptoms persisting for at
Urvi Ray, Urvi Ray, Antje Schulze Selting, Antje Schulze Selting, Roshan Priyarangana Perera, Zhiqi Yang, Vladislav Lysenkov, Vladislav Lysenkov, Siri Göpel, Siri Göpel, Michael Bitzer, Madhuri S. Salker, Madhuri S. Salker, Madhuri S. Salker, Madhuri S. Salker, Stephan Ossowski, Stephan Ossowski, Olaf Riess, Olaf Riess, Nicolas Casadei, Nicolas Casadei, Yogesh Singh, Yogesh Singh, Yogesh Singh   +23 more
doaj   +1 more source

Microbiological Diagnostic Performance of Metagenomic Next-generation Sequencing When Applied to Clinical Practice.

Clinical Infectious Diseases, 2018
Background Metagenomic next-generation sequencing (mNGS) was suggested to potentially replace traditional microbiological methodology because of its comprehensiveness.
Qing Miao, Yuyan Ma, Qingqing Wang, Jue Pan, Yao Zhang, Wenting Jin, Yumeng Yao, Yi Su, Yingnan Huang, Mengran Wang, Bing-Yu Li, Huayin Li, Chunmei Zhou, Chun Li, M. Ye, Xiaolin Xu, Yong-jun Li, Bijie Hu   +17 more
semanticscholar   +1 more source