Results 71 to 80 of about 1,096,418 (305)
Frontiers in Virology, 2022 Since the COVID-19 outbreak emerged, SARS-CoV-2 has continuously evolved into variants with underlying mutations associated with increased transmissibility, potential escape from neutralizing antibodies, and disease severity.
Peter Mwangi +31 more
doaj +1 more source
Molecular & Cellular Proteomics, 2021 Understanding the dynamics of the human proteome is crucial for developing biomarkers to be used as measurable indicators for disease severity and progression, patient stratification, and drug development.
Lotta Wik +11 more
semanticscholar +1 more source
Next Generation Sequence Assembly with AMOS [PDF]
Current Protocols in Bioinformatics, 2011 AbstractA Modular Open‐Source Assembler (AMOS) was designed to offer a modular approach to genome assembly. AMOS includes a wide range of tools for assembly, including the lightweight de novo assemblers Minimus and Minimo, and Bambus 2, a robust scaffolder able to handle metagenomic and polymorphic data. This protocol describes how to configure and use
Treangen, Todd J. +4 more
openaire +5 more sources
Immunoglobulin Depletion and Recovery Following Blinatumomab in Infants With KMT2A‐Rearranged ALL
Pediatric Blood &Cancer, EarlyView.ABSTRACT Adding blinatumomab to standard chemotherapy for infants with KMT2A‐rearranged acute B‐cell lymphoblastic leukemia (KMT2A‐r B‐ALL) improves outcomes. Although blinatumomab impairs immunoglobulin G (lgG) production, increasing infection susceptibility, IgG recovery remains poorly understood.
Miguel Vieira Martins +14 more
wiley +1 more source
BMC Genomics, 2012 BackgroundNext generation sequencing (NGS) technology has revolutionized genomic and genetic research. The pace of change in this area is rapid with three major new sequencing platforms having been released in 2011: Ion Torrent’s PGM, Pacific Biosciences’
M. Quail +8 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider +15 more
wiley +1 more source
Communications BiologyBoth bacterial and viral infections can trigger an overwhelming host response, leading to immunopathology and organ dysfunction. Multiple studies have reported dysregulated myeloid cell states in patients with bacterial sepsis or severe SARS-CoV-2 ...
Kimberly Kajihara +14 more
doaj +1 more source
Rapid Pathogen Detection by Metagenomic Next-Generation Sequencing of Infected Body Fluids
Nature Medicine, 2020 We developed a metagenomic next-generation sequencing (mNGS) test using cell-free DNA from body fluids to identify pathogens. The performance of mNGS testing of 182 body fluids from 160 patients with acute illness was evaluated using two sequencing ...
W. Gu +21 more
semanticscholar +1 more source
A Comprehensive Review of Performance of Next-Generation Sequencing Platforms
BioMed Research International, 2022 Background Next-generation sequencing methods have been developed and proposed to investigate any query in genomics or clinical activity involving DNA.
M. T. Pervez +5 more
semanticscholar +1 more source
Next-Generation Sequencing: The Race Is On [PDF]
Cell, 2008 The $1000 genome may still be years away, but with the arrival of next-generation sequencing (NGS) technologies that are much faster and cheaper than the traditional Sanger method, large-scale sequencing of hundreds or even thousands of human genomes is fast becoming reality.
openaire +2 more sources