Results 191 to 200 of about 1,444,385 (351)

Optimized Nuclear Pellet Method for Extracting Next-Generation Sequencing Quality Genomic DNA from Fresh Leaf Tissue [PDF]

, 2019
Md Masud Rana, Murat Aycan, Takeshi Takamatsu, Kentaro Kaneko, Toshiaki Mitsui, K. Itoh   +5 more
openalex   +1 more source

eP484: Scaling a high throughput next generation sequencing laboratory for community surveillance of SARS-CoV-2 viral variants during the public health crisis

, 2022
Holly Houdeshell, Alec Vest, Dillon Nall, Vikram Ghorpade, Rob Case, Matthew Hardison, Cyndi Clark   +6 more
openalex   +2 more sources

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

CloneRetriever: An Automated Algorithm to Identify Clonal B and T Cell Gene Rearrangements by Next-Generation Sequencing for the Diagnosis of Lymphoid Malignancies [PDF]

, 2021
Eitan Halper‐Stromberg, Chad M. McCall, Lisa Haley, Ming-Tseh Lin, Samantha L. Vogt, Christopher D. Gocke, James R. Eshleman, Wendy Stevens, Neil Martinson, Marta Epeldegui, Matthias Holdhoff, Chetan Bettegowda, Michael Glantz, Richard F. Ambinder, Rena R. Xian   +14 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Editorial: Application of next-generation sequencing in clinical settings. [PDF]

Front Genet
Chai Z, Mei H, Li Q, Maqsood I, Cai J, Li MM, Xu F, Zhao X.   +7 more
europepmc   +1 more source

Characterizing natural variation using next-generation sequencing technologies

, 2009
Yoav Gilad, Jonathan K. Pritchard, Kevin Thornton   +2 more
openalex   +2 more sources

Using next‐generation sequencing to detect oral microbiome change following periodontal interventions: A systematic review

, 2020
Ya Zhang, Yinliang Qi, Edward Chin Man Lo, Colman McGrath, May Lei Mei, Ruoxi Dai   +5 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Next-Generation Sequencing in Infectious-Disease Diagnostics: Economic, Regulatory, and Clinical Pathways to Adoption. [PDF]

Microbiologyopen
Osei Sekyere J.
europepmc   +1 more source