Results 211 to 220 of about 1,096,418 (305)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

RNA-based next-generation sequencing strategy for screening MDM2-amplified sarcomas. [PDF]

Sci Rep
Lei C, Zang H, Zhang H, He Y, Zhang M, Sun Y, Fan S, Zhou P.   +7 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Analytical validation of a highly accurate and reliable next-generation sequencing-based urine assay. [PDF]

Microbiol Spectr
Couto-Rodriguez M, Danko DC, Wells HL, Rey S, Jirau Serrano X, Fidler G, Papciak J, Combs PF, Plourde A, Augenbraun M, Mason CE, Otto C, O'Hara NB, Nagy-Szakal D.   +13 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Next-Generation Sequencing Strategies During the 2024-2025 Avian Influenza A(H5N1) Emergency Response in the U.S. [PDF]

Viruses
Frederick JC, Lacek KA, Wersebe MJ, Shu B, Keong LM, DaSilva J, Wilson MM, Sheffield SR, Liddell J, Burnett N, Chau R, Sullivan AH, Jang Y, De La Cruz JA, Pusch EA, Cui D, Hatta Y, Schatzman S, Hassell N, Zheng XY, Nguyen HT, Gubareva L, Kondor R, Di H, Dugan VG, Davis CT, Rambo-Martin BL, Kirby MK.   +27 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Utilities of next-generation sequencing in the surgical management of thyroid nodules in China. [PDF]

BMC Endocr Disord
Lin K, Xin X, Liu J, Shi F, Zheng L, He Q, Ma Y.   +6 more
europepmc   +1 more source

The impact of next-generation sequencing technology on genetics.

Trends in Genetics, 2008
E. Mardis
semanticscholar   +1 more source