Results 51 to 60 of about 978,334 (297)

Next-Generation Sequencing Strategies [PDF]

Cold Spring Harbor Perspectives in Medicine, 2018
More than a decade ago, the term "next-generation" sequencing was coined to describe what was, at the time, revolutionary new methods to sequence RNA and DNA at a faster pace and cheaper cost than could be performed by standard bench-top protocols. Since then, the field of DNA sequencing has evolved at a rapid pace, with new breakthroughs allowing ...
Shawn E, Levy, Braden E, Boone
openaire   +2 more sources

WaveCNV: allele-specific copy number alterations in primary tumors and xenograft models from next-generation sequencing. [PDF]

, 2013
MotivationCopy number variations (CNVs) are a major source of genomic variability and are especially significant in cancer. Until recently microarray technologies have been used to characterize CNVs in genomes.
Ali, Johar, Arshadi, Niloofar, Beck, Tim, Holt, Carson, Jang, Gun Ho, Losic, Bojan, McPherson, John, Muthuswamy, Lakshmi B, Pai, Deepa, Syam, Sujata, Trinh, Quang, Zhao, Zhen   +11 more
core   +3 more sources

High Detection Frequency of Vaccine-Associated Polioviruses and Non-Polio Enteroviruses in the Stools of Asymptomatic Infants from the Free State Province, South Africa

Microorganisms
Enterovirus (EV) infections are widespread and associated with a range of clinical conditions, from encephalitis to meningitis, gastroenteritis, and acute flaccid paralysis.
Milton T. Mogotsi, Ayodeji E. Ogunbayo, Hester G. O’Neill, Martin M. Nyaga   +3 more
doaj   +1 more source

Suppressing gain-of-function proteins via CRISPR/Cas9 system in SCA1 cells

Scientific Reports, 2022
SCAs are autosomal dominant neurodegenerative disorders caused by a gain-of-function protein with toxic activities, containing an expanded polyQ tract in the coding region.
Mariangela Pappadà, Ottavia Bonuccelli, Mattia Buratto, Riccardo Fontana, Mariaconcetta Sicurella, Anna Caproni, Silvia Fuselli, Andrea Benazzo, Roberto Bertorelli, Veronica De Sanctis, Paolo Cavallerio, Valentina Simioni, Valeria Tugnoli, Francesca Salvatori, Peggy Marconi   +14 more
doaj   +1 more source

Virtual Environment for Next Generation Sequencing Analysis [PDF]

, 2012
Next Generation Sequencing technology, on the one hand, allows a more accurate analysis, and, on the other hand, increases the amount of data to process.
Abate, Francesco, Acquaviva, Andrea, Mossucca, L., Provenzano, R., Terzo, Olivier   +4 more
core  

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Next generation sequencing [PDF]

, 2013
Informacije pohranjene u DNA sekvenci sadrži vrijedne podatke o tom organizmu, i znajući sekvencu cijelog genoma, u mogućnosti smo razumjeti procese koji se odvijaju u tom biću.
Vučenović, Dunja
core   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Accurate long-read transcript discovery and quantification at single-cell, pseudo-bulk and bulk resolution with Isosceles

Nature Communications
Accurate detection and quantification of mRNA isoforms from nanopore long-read sequencing remains challenged by technical noise, particularly in single cells. To address this, we introduce Isosceles, a computational toolkit that outperforms other methods
Michal Kabza, Alexander Ritter, Ashley Byrne, Kostianna Sereti, Daniel Le, William Stephenson, Timothy Sterne-Weiler   +6 more
doaj   +1 more source

Soil microbial load modulation improves plant–microbe interactions and bioinoculant efficacy in pathogen-stressed soils

Frontiers in Plant Science
Plants establish a close association with a community of microbes naturally living in the soil, known as resident soil microbiome, which typically maintains a dynamic equilibrium that confers resilience against biotic and abiotic perturbations.
Yohannes Ebabuye Andargie, Yohannes Ebabuye Andargie, GyuDae Lee, Min-Ji Kim, Eskindir Getachew Fentie, Minsoo Jeong, Setu Bazie Tagele, Kyeongmo Lim, Ugur Azizoglu, Ugur Azizoglu, Jae-Ho Shin, Jae-Ho Shin, Jae-Ho Shin   +12 more
doaj   +1 more source