Results 61 to 70 of about 10,054 (203)

Oncolytic Adenovirus Armed with a Novel Agonist of the CD137 Immune Checkpoint Stimulator Suppresses Tumor Growth

Vaccines
Natural 4-1BBL (CD137L) is a cell membrane-bound protein critical to the expansion, effector function, and survival of CD8+ T cells. We reported the generation of an active soluble oligomeric construct, SA-4-1BBL, with demonstrated immunoprevention and ...
Martin R. Ramos-Gonzalez, Mohammad Tarique, Lalit Batra, Feyza Arguc, Rodolfo Garza-Morales, Haval Shirwan, Esma S. Yolcu, Jorge G. Gomez-Gutierrez   +7 more
doaj   +1 more source

Refining Domain‐Based Prognostication in DNM1 Encephalopathy: A Mild Phenotype Associated With a GTPase Domain Variant

American Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2558-2561, November 2026.
ABSTRACT DNM1 encephalopathy is a rare autosomal dominant genetic condition characterized by a range of neurological and developmental manifestations. The typical phenotype is severe, including profound intellectual disability, treatment‐resistant epilepsy, ataxia, and structural brain abnormalities. However, milder presentations have increasingly been
Caroline Crain, Hope Northrup, Laura S. Farach, Sureni V. Mullegama, Kathleen Shields, Gretchen Von Allmen, Kate Richardson   +6 more
wiley   +1 more source

Prevalence of newly diagnosed hypertension in patients presenting with stroke at the medical emergency Department of Rwanda Military Referral and Teaching Hospital: a five-years retrospective study (2020–2025)

BMC Neurology
Background Hypertension is a leading modifiable risk factor for stroke, especially in low- and middle-income countries. In Rwanda, stroke remains a significant public health concern; however, local data on the epidemiological profile of hypertension ...
Aime Ishimwe Mugisha, Olivier Uwishema, Isaie Nzayisenga, Faustin Munyaneza   +3 more
doaj   +1 more source

Tropical Plantains, Tubers, and Roots: Advancing Food Quality, Safety, and Processing Innovations for Global Nutritional Equity

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Plantains, tubers, and roots (PTRs) represent strategic nutritional and caloric pillars for over 500 million people across tropical regions. This review evaluates traditional bioprocessing against eco‐innovative thermomechanical and non‐thermal technologies (HPP, extrusion, encapsulation) to overcome severe post‐harvest losses and antinutritional risks.
Mundéné‐Timothée Junior Lawrence, Veeranna Hitlamani, Njintang Yanou Nicolas, Aashitosh A. Inamdar   +3 more
wiley   +1 more source

Head-Worn Displays for NextGen [PDF]

, 2011
The operating concepts emerging under the Next Generation air transportation system (NextGen) require new technology and procedures - not only on the ground-side - but also on the flight deck.
Arthur, J. J., Shelton, Kevin J., Bailey, Randall E.   +2 more
core  

NextGen VOICES: Research resolutions

Science, 2018
We asked young scientists this question: What is your New Year's resolution for your field? Describe one thing that your field's research community could do better in the coming year . We received responses from scientists around the world representing a variety of fields.
Olmeta-Schult F, Segal LM, Tyner S, Moon TA, Chow RD, Chakrabarty P, Pacesa M, Podgornaia AI, Chen J, Singh B, Cao B, Sidhu RRS, Tan BWQ, Sood P, Parker S, Scult MA, Van Haute D, Konstantinides N, Schwendimann BA, Srivastava S, Fiorenza R, Dutton-Regester K, Hale R, Polat EO, Lau E, Mayer AL, White ER   +26 more
openaire   +4 more sources

PDBe‐SIFTS: An open‐source tool for Structure Integration with Function, Taxonomy, and Sequences, featuring improved alignment, scoring scheme, and accelerated search

Protein Science, Volume 35, Issue 11, November 2026.
Abstract Structure integration with function, taxonomy and sequences (SIFTS) provides residue‐level mappings between UniProt Knowledgebase sequences and Protein Data Bank structures and has historically been generated through internal Protein Data Bank in Europe (PDBe) pipelines.
Adam Bellaiche, Preeti Choudhary, Sreenath Nair, Deborah Harrus, Conny Wing‐Heng Yu, Syed Ahsan Tanweer, Genevieve Laura Evans, Stephanie W. Lo, Maria J. Martin, Jennifer R. Fleming, Sameer Velankar   +10 more
wiley   +1 more source

The 4th NextGen therapies for SJIA and MAS: part 3 clinical trials in refractory SJIA: historic controls as an alternative to a withdrawal design study

Pediatric Rheumatology Online Journal
The substantial morbidity and mortality associated with refractory systemic JIA underlies the need for new treatment approaches. However, progress in this area has been limited by the difficulty of enrolling these patients in clinical trials with ...
Fabrizio de Benedetti, Alexei A. Grom, Hermine Brunner   +2 more
doaj   +1 more source

Impact Crater Hydrothermal Systems Support Rapid Microbial Enrichment and Diverse Metabolic Potential

Geobiology, Volume 24, Issue 6, November/December 2026.
ABSTRACT Impact crater hydrothermal systems, formed after asteroid and comet impacts, have been proposed as promising habitats for life on early Earth and as key targets in the search for life on planetary bodies such as Mars, since they provide liquid water and active geochemical turnover.
Sabrina M. C. Hardy, Emily J. Aguilar‐Pine, Sean Gulick, Alaa Ahmad, Brett J. Baker, Nathalie Scott, Georgina Aitolo, Naomi Felton, Charles S. Cockell   +8 more
wiley   +1 more source

Challenges and Risks Involved in Deploying 6G and NextGen Networks

, 2022
This book examines the challenges of next-generation (NextGen) networks, emphasizing the role of artificial intelligence in enhancing privacy and security. It explores strategies for designing secure, user-centered NextGen networks, addressing political,
Alhadidi B., Viswa A. M. B., Viswa A. M. B., Alhadidi B.   +2 more
core   +2 more sources