Results 191 to 200 of about 396,196 (289)

NF-κB restrains nutrient-dependent transcription programs through chromatin modulation in Drosophila. [PDF]

Nucleic Acids Res
Kong X, Li C, Karpac J.
europepmc   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

NF-κB and pulmonary hypertension: Advances in mechanistic research and therapeutic applications. [PDF]

Am Heart J Plus
Si M, Hu Y, Jin Z, Mao Y, Kang L.
europepmc   +1 more source

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

Current Perspectives on the NF-κB Signaling Axis as a Potential Pharmacological Target in Cardiorenal Syndrome. [PDF]

Drug Des Devel Ther
Liu Q, Wang X, Cheng P, Yang T, Wang C, Zhou H.   +5 more
europepmc   +1 more source

Deregulation of Tpl2 and NF-κB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium

, 2008
Minying Zhang, Wei Jin, Xiaofei Zhou, Jiayi Yu, Andrew Lee, Shao‐Cong Sun   +5 more
openalex   +1 more source

CXC Chemokine Ligand 2 Induced by Receptor Activator of NF-κB Ligand Enhances Osteoclastogenesis [PDF]

, 2010
Jeongim Ha, Hyo-Sun Choi, Youngkyun Lee, Hyung‐Joo Kwon, Yeong Wook Song, Hong‐Hee Kim   +5 more
openalex   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Alteration of CD40 Protein Expression by Tyrosine Phosphorylation of the NF-κB p50 Subunit. [PDF]

Chembiochem
Chen S, Potuganti GR, Ji X, Hecht SM.
europepmc   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source