Results 211 to 220 of about 396,196 (289)

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

RIPK2 induces docetaxel resistance in prostate cancer through the NF-κB/P-gp signaling pathway. [PDF]

PLoS One
Xing S, Xu Z, Zeng S, Yue M, Xing W, Liu Q.   +5 more
europepmc   +1 more source

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

The LXRβ/NF-κB axis reprograms CAR-T cells to resist exhaustion in the tumor microenvironment. [PDF]

Oncoimmunology
Lim M, Jung SE, Koh CH, Jeong H, Moon Y, Seo H.   +5 more
europepmc   +1 more source

Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury [PDF]

Xin Yu, Yujing Song, Tao Dong, Wenlu Ouyang, Chao Quan, Liu-Jia-Zi Shao, Leonard Barasa, Paul Thompson, Mao Zhang, Jianjie Ma, Katsuo Kurabayashi, Yongqing Li   +11 more
openalex   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Remimazolam alleviates cerebral ischemia-reperfusion injury of rats by inhibiting NF-κB/NLRP3 inflammasome pyroptosis. [PDF]

Sci Rep
Liu T, Chen J, Shi M, Li C, Dai W, Chen C, Xie Y.   +6 more
europepmc   +1 more source

TMEM131‐Mediated Soluble TRAIL Triggered Type II Alveolar Epithelial Cell Senescence in Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Linzhi Han, Chunsheng Wang, Xiuli Guo, Yuan Luo, Jianguo Zhang, Fajian He, Zihang Zeng, Jiang Luo, Wen Ouyang, Yan Gong, Conghua Xie   +10 more
wiley   +1 more source

Friedelin Ameliorates Nucleus Pulposus Inflammation by Increasing p65 Autophagic Degradation to Inhibit NF-κB Signalling Pathway. [PDF]

J Cell Mol Med
Tu K, Liao D, Chen Z, Wang Z, Zhao K, Zhong H, Wu S, Zhu H, Xu J, Zhou B, Dai X, Wu Q.   +11 more
europepmc   +1 more source

Involvement of Two NF-κB Binding Sites in PMA-induced Expression of the Human Leukotactin-1/CCL15 Gene in U937 Monocytoid Cells

, 2004
Yong‐Hyun Shin, Jung‐Jae Shim, Man‐Wook Hur, Chang-Joong Kang, Jiyoung Kim   +4 more
openalex   +1 more source