Results 141 to 150 of about 270,662 (312)

Integrative single cell RNA‐sequencing and spatial transcriptomics uncovers distinct macrophage‐fibroblast cross‐talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell‐cell interactions in FAI and hip OA.
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia‐Lung Wu   +9 more
wiley   +1 more source

Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang, Norzawani Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew C. Pickering, Marina Botto, Emma E. Davenport   +9 more
wiley   +1 more source

Inflammatory gene mRNA expression in human peripheral blood and its association with colorectal cancer

Journal of Inflammation Research, 2018
Reem Abdullah Alamro,1 Mohammad Mustafa,2 Abdulrahman K Al-Asmari2 1Deparment of Gastroenterology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia; 2Research Centre, Prince Sultan Military Medical City, Riyadh, Saudi Arabia Objective: The ...
Alamro RA, Mustafa M, Al-Asmari AK
doaj  

Galectin-3 promotes calcification of human aortic valve interstitial cells via the NF-kappa B signaling pathway. [PDF]

Cardiovasc Diagn Ther, 2022
Luo J, Wang S, Liu X, Zheng Q, Wang Z, Huang Y, Shi J.   +6 more
europepmc   +1 more source

Gli Transcriptional Activity Is Essential for Kras-Induced Pancreatic Tumorigenesis and Regulates IKBKE/NF-\(\kappa\)B Activity in the Tumor Epithelium [PDF]

, 2012
Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive human malignances, is thought to be initiated by KRAS activation. Here we find that transcriptional activation mediated by the Gli family of transcription factors, although dispensable ...
Appleman, Victoria A., Cotton, Jennifer, de Jesus-Monge, Wilfredo E., Driscoll, David R., Huang, He, Klimstra, David, Lewis, Brian, Mao, Junhao, McMahon, Andrew P., Rajurkar, Mihir, Simin, Karl, Xu, Lan, Zhu, Lihua   +12 more
core  

A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still's Disease‐like Autoinflammatory Syndrome

Arthritis &Rheumatology, Accepted Article.
Objectives Still's Disease represents a prototypical polygenic systemic autoinflammatory diseases (SAIDs), characterized by recurrent systemic inflammation and dysregulation of innate immunity. Despite extensive clinical characterization, familial clustering Still's disease remains unreported.
Longfang Chen, Qihua Dai, Yu Xiao, Jialin Dai, Mengyan Wang, Yuning Ma, Yujie Shen, Zhimo Xu, Jianfen Meng, Xia Chen, Da Yi, Yue Sun, Hui Shi, Honglei Liu, Xiaobing Cheng, Yutong Su, Junna Ye, Huihui Chi, Zhuochao Zhou, Tingting Liu, Jialin Teng, Chengde Yang, Jinchao Jia, Qiongyi Hu   +23 more
wiley   +1 more source

Nuclear factor-kappa B and diabetic nephropathy

Linchuang shenzangbing zazhi, 2019
Diabetes is a metabolic disease that affects most of the world’s population. Diabetic nephropathy(DN) is the main complication of diabetes mellitus and the main cause of end-stage renal diseases.
TAN Xiao-yan, YANG Ding-ping, DING Guohua   +2 more
doaj  

NF-kappa-B activation unveils the presence of inflammatory hotspots in human gut xenografts. [PDF]

PLoS One, 2021
Nissim-Eliraz E, Nir E, Marsiano N, Yagel S, Shpigel NY.   +4 more
europepmc   +1 more source

Bacterial Pigments as Potential Antitumor Agents Against Gastrointestinal Cancers: A Comprehensive Systematic Review

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Gastrointestinal cancers (GICs) constitute one of the leading causes of cancer‐related morbidity and mortality worldwide. Despite currently available therapeutic strategies, new approaches and procedures are needed for their prevention and treatment.
Raúl Vergara, Ricardo F. S. Pereira, Carla C. C. R. de Carvalho, Jose Prados, Consolación Melguizo, Raul Ortiz   +5 more
wiley   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source