Results 1 to 10 of about 4,694 (96)

NFATc Acts as a Non-Canonical Phenotypic Stability Factor for a Hybrid Epithelial/Mesenchymal Phenotype

Frontiers in Oncology, 2020
Metastasis remains the cause of over 90% of cancer-related deaths. Cells undergoing metastasis use phenotypic plasticity to adapt to their changing environmental conditions and avoid therapy and immune response.
Ayalur Raghu Subbalakshmi, Deepali Kundnani, Kuheli Biswas, Anandamohan Ghosh, Samir M. Hanash, Satyendra C. Tripathi, Satyendra C. Tripathi, Mohit Kumar Jolly   +7 more
doaj   +3 more sources

Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?

Cell Communication and Signaling, 2009
The drugs cyclosporine A (CsA) and tacrolimus (FK506) revolutionized organ transplantation. Both compounds are still widely used in the clinic as well as for basic research, even though they have dramatic side effects and modulate other pathways than ...
Baumgrass Ria, Sieber Matthias
doaj   +3 more sources

Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl Isomerization. [PDF]

PLoS ONE, 2015
A limited repertoire of PPP family of serine/threonine phosphatases with a highly conserved catalytic domain acts on thousands of protein targets to orchestrate myriad central biological roles.
Alicia Guasch, Álvaro Aranguren-Ibáñez, Rosa Pérez-Luque, David Aparicio, Sergio Martínez-Høyer, M Carmen Mulero, Eva Serrano-Candelas, Mercè Pérez-Riba, Ignacio Fita   +8 more
doaj   +1 more source

Architecture and expression of the Nfatc1 gene in lymphocytes

Frontiers in Immunology, 2014
In lymphocytes, the three NFAT factors NFATc1 (also designated as NFAT2), NFATc2 (NFAT1) and NFATc3 (NFAT4 or NFATx) are expressed and are targets of immune receptor signals which lead to a rapid rise of intracellular Ca++, the activation of phosphatase ...
Ronald eRudolf, Rhoda eBusch, Amiya Kumar Patra, Khalid eMuhammad, Andris eAvots, Jean-Christophe eAndrau, Stefan eKlein-Hessling, Edgar eSerfling   +7 more
doaj   +1 more source

Nuclear factor of activated T-cells (NFATC) as a possible diagnostic and prognostic marker in congenital valvular diseases and myocardial hypertrophy

Patologìâ, 2014
Aim. The nuclear factor of activated T-cells (NFATc 1-4) family gene expression against the background of cardiovascular disorders, accompanying both congenital heart diseases (mainly ones involving valvular defects) and arterial hypertension, is ...
А. V. Kamenshchyk, O. G. Ivanko, A. V. Fеdchеnkо   +2 more
doaj   +1 more source

The role of single nucleotide polymorphisms of NFATC genes in the development of left ventricular hypertrophy in primary arterial hypertensive adolescents

Patologìâ, 2017
The aim of the study was to determine the possibility of association of the single nucleotide polymorphisms (SNP) of NFATC1 and NFATC4 genes with the development of concentric hypertrophy of the left ventricle (LVH) in adolescents aged 16-18 with newly ...
A.V. Tovma, A. M. Kamyshnyi, A. V. Kamenshchyk, O. G. Ivanko   +3 more
doaj   +1 more source

Transcriptional profiling of innate immune responses in sheep PBMCs induced by Haemonchus contortus soluble extracts

Parasites & Vectors, 2019
Background Pattern recognition receptors (PRRs) can recognize pathogen-associated molecular patterns and activate downstream signalling pathways, resulting in modulation of host immunity against pathogens.
Si Wang, Dandan Hu, Chaoyue Wang, Xinming Tang, Mengze Du, Xiaolong Gu, Jingxia Suo, Min Hu, Rui Fang, Xingquan Zhu, Xichen Zhang, Aifang Du, Xun Suo, Xianyong Liu   +13 more
doaj   +1 more source

NFATc1/αA: The other Face of NFAT Factors in Lymphocytes

Cell Communication and Signaling, 2012
In effector T and B cells immune receptor signals induce within minutes a rise of intracellular Ca++, the activation of the phosphatase calcineurin and the translocation of NFAT transcription factors from cytosol to nucleus.
Serfling Edgar, Avots Andris, Klein-Hessling Stefan, Rudolf Ronald, Vaeth Martin, Berberich-Siebelt Friederike   +5 more
doaj   +1 more source

NFAT activation by FKBP52 promotes cancer cell proliferation by suppressing p53

Life Science Alliance
FKBP52 promotes nuclear translocation of NFATc, which activates MDM2 transcription, thus suppressing p53 expression and promoting cell proliferation. FK506-binding protein 52 (FKBP52) is a member of the FKBP family of proline isomerases.
Shunsuke Hanaki, Makoto Habara, Haruki Tomiyasu, Yuki Sato, Yosei Miki, Takahiro Masaki, Shusaku Shibutani, Midori Shimada   +7 more
doaj   +1 more source

Expression and Significance of COX-2 and its Transcription Factors NFAT3 and c-Jun in Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2010
Background and objective Cyclooxygenases (COX), the key enzymes in the conversion of arachidonic acid (AA) to prostaglandins (PGs), are involved in initiation and progression of cancer.
Xiaohong ZHAO, Zhaoli CHEN, Shouhua ZHA, Jie HE   +3 more
doaj   +1 more source