Results 11 to 20 of about 4,694 (96)

Single-Cell Sequencing and Mendelian Randomization Reveal T Cell Nuclear Factor Genes in Hepatocellular Carcinoma Progression. [PDF]

Hum Mutat
This study integrates single‐cell RNA sequencing with Mendelian randomization to elucidate the role of nuclear factor of activated T cells (NFAT)‐related genes in the progression of hepatocellular carcinoma (HCC). The GSE162616 dataset was analyzed to identify differentially expressed cells and NFAT‐related genes through quality control, clustering ...
Chen Y, Yang X, Zhong L, Chen K, Luo L.
europepmc   +2 more sources

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Molecular Basis and Clinical Spectrum of WNT10A‐Related Oligodontia

Clinical Genetics, Volume 110, Issue 1, Page 3-14, July 2026.
Cellular Mechanism behind WNT10A phenotypes. ABSTRACT WNT10A mutations, a major genetic determinant of dental agenesis and ectodermal dysplasia, exert profound effects on craniofacial development. Although classified as rare disorders, these mutations account for more than half of oligodontia cases, reflecting their critical role.
Perennes Elise, Benkirane‐Jessel Nadia, Anton Nicolas, Vandamme Thierry, Clauss François, Conzatti Guillaume   +5 more
wiley   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, Volume 13, Issue 26, 8 May 2026.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Targeting Sphingosine‐1‐Phosphate Signaling Attenuates Doxorubicin‐Aggravated Bone Loss in Obese Breast Cancer Mice

Smart Medicine, Volume 5, Issue 2, April 2026.
During obese breast cancer‐bearing mice undergoing chemotherapy, DOX increases the concentration of S1P produced by breast cancer cells, which induces osteoclastogenesis through the activation of the S1PR1/p‐STAT3/NFATc‐1 pathway, thereby exacerbating bone loss in the breast cancer‐bearing mice with high‐fat dietary.
Yu Zhang, Hao Shen, Junjie Niu, Yingkang Huang, Can Zhu, Yi Wang, Yida Chen, Xinyi Cheng, Huilin Yang, Xianrong Zhang, Hao Chen, Hongbo Zhang, Qin Shi   +12 more
wiley   +1 more source

A Circadian Trough in Glucocorticoid Signaling Is Essential for Bone Health in Mice

Aging Cell, Volume 25, Issue 4, April 2026.
Flattening the circadian rhythm of endogenous glucocorticoids induces osteoporosis in mice. We demonstrate that reinstating a trough in glucocorticoid receptor signaling stimulates bone formation and suffices to prevent osteoporosis. Reinstating the trough at its natural time of day is needed for full protection.
Annelies E. Smit, Kaiming Yue, Sander Kooijman, Salwa Afkir, Maaike Schilperoort, Marijke Koedam, Bram C. J. van der Eerden, Jan Kroon, Onno C. Meijer, Elizabeth M. Winter   +9 more
wiley   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, Volume 12, Issue 1, Page 96-122, Spring 2026.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

The Flavonoid Kaempferol Mitigates Periprosthetic Osteolysis by Regulating the NLRP3 Inflammasome and Balancing Bone Metabolism

Journal of Cellular and Molecular Medicine, Volume 29, Issue 19, October 2025.
ABSTRACT Total joint arthroplasty (TJA) is an effective intervention for end‐stage arthritis; however, its long‐term success is often compromised by wear particle–induced osteolysis, leading to aseptic loosening and implant failure. This study investigates the potential of kaempferol (Ka), a natural flavonoid with anti‐inflammatory properties, to ...
Cheng Huang, Chenhui Zhang, Yongjun Luo, Lujun Guo, Yanglin Wu, Qingyan Shi, Yazhong Zhang, Chengyuan Yang, Bo Wang, Junjie Niu, Jun Lin   +10 more
wiley   +1 more source

Preclinical Vocal Fold and Airway Injury Models: A Scoping Review

Laryngoscope Investigative Otolaryngology, Volume 10, Issue 4, August 2025.
Preclinical models are necessary to study novel therapeutics for laryngotracheal diseases. Currently, no consensus on species, injury mechanics, and study duration exists. This study reviews and organizes approaches to vocal fold (VF) and laryngotracheal injuries in preclinical models.
Rahul D. Patel, Nour Awad, Denzel Ryan D. Cruz, Aida M. Hasson, Cameron D. Cook, Danielle Hall, Gregory R. Dion   +6 more
wiley   +1 more source