Results 21 to 30 of about 4,694 (96)

Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms

Journal of Pineal Research, Volume 77, Issue 4, July 2025.
ABSTRACT Melatonin is a versatile neurohormone with diverse molecular functions, including sleep regulation, inflammation reduction, antioxidant activity, immune modulation, and anticancer properties. In bone metabolism, it promotes osteoblast formation, inhibits osteoclast activity, and synchronizes skeletal tissue rhythms to support bone health.
Ko‐Hsiu Lu, Yi‐Hsien Hsieh, Renn‐Chia Lin, Meng‐Ying Tsai, Shun‐Fa Yang   +4 more
wiley   +1 more source

RNA‐Sequencing in Elucidating Immune Responses to Haemonchus contortus Infection in Small Ruminants: Systematic Review

Parasite Immunology, Volume 47, Issue 5, May 2025.
ABSTRACT Haemonchus contortus poses a major threat to small ruminant production in subtropical regions worldwide. Unfortunately, there is growing anthelmintic resistance, and the only licensed vaccine has limitations. This paper aimsto review the use of RNA‐sequencing in understanding the immune responses of small ruminants to H.
Bongeka Sylvia Ndaba, Erika Faber, Munyaradzi Christopher Marufu, Alri Pretorius, Selaelo Ivy Tshilwane   +4 more
wiley   +1 more source

The Two Faces of Angiopoietin‐Like Protein 2 in Cancer

Cancer Science, Volume 116, Issue 3, Page 592-599, March 2025.
In this Review, Horiguchi et al. focus on ANGPTL2 activity in the tumor microenvironment and its function in anti‐cancer immunity. ABSTRACT The tumor microenvironment is composed of tumor cells and various stromal cell types, such as immune cells, fibroblasts, and vascular cells.
Haruki Horiguchi, Tsuyoshi Kadomatsu, Yuichi Oike   +2 more
wiley   +1 more source

NFAT1 Signaling Contributes to Bone Cancer Pain by Regulating IL‐18 Expression in Spinal Microglia

CNS Neuroscience &Therapeutics, Volume 31, Issue 2, February 2025.
Schematic illustration of glia–neuron interactions in the spinal cord dorsal horn in bone cancer pain. NFAT1 is upregulated in spinal microglia in Lewis lung carcinoma‐induced bone cancer pain. Upon activation, microglia synthesize and release IL‐18 through p38 MAPK phosphorylation, leading to enhanced activation of the NMDA receptor and the subsequent
Xuetai Chen, Ying Zeng, Zizhu Wang, Jixiang Zhu, Fengyun Liu, Mingxuan Zhu, Jiayi Zheng, Qingdaiyao Chen, Dongxu Zhai, Yangyang Chen, Jiayao Niu, Zhouya Xue, Guan Sun, Feng Li, Zhiqiang Pan   +14 more
wiley   +1 more source

Fused extracellular vesicles from M2 macrophages and human umbilical cord mesenchymal stem cells for the targeted regulation of macrophage pyroptosis in periprosthetic osteolysis

Journal of Extracellular Vesicles, Volume 13, Issue 12, December 2024.
Abstract The development of strategies for the prevention and treatment of aseptic loosening of prostheses stands as a critical area of global research interest. The pyroptosis of local macrophages triggered by wear particles plays a pivotal role in the onset of periprosthetic osteolysis and subsequent loosening.
Qimeng Liu, Tianliang Ma, Zheyu Zhang, Jiangyu Nan, Guanzhi Liu, Yute Yang, Yihe Hu, Jie Xie   +7 more
wiley   +1 more source

Genomic responses to climatic challenges in beef cattle: A review

Animal Genetics, Volume 55, Issue 6, Page 854-870, December 2024.
Abstract Climate change is a major concern for the near future and for livestock breeding. Cattle breeding, due to its greenhouse gas emissions, is one of the most implicated industries. Consequently, the main future goals are to breed animals resilient to climate change, with the aim of lowering the livestock impact on the environment and selecting ...
Daniele Colombi, Francesco Perini, Stefano Bettini, Salvatore Mastrangelo, Fabio Abeni, Giuseppe Conte, Donata Marletta, Martino Cassandro, Umberto Bernabucci, Roberta Ciampolini, Emiliano Lasagna   +10 more
wiley   +1 more source

Calcineurin inhibitors and the renin–angiotensin–aldosterone system

Acta Physiologica, Volume 240, Issue 12, December 2024.
Abstract Calcineurin inhibitors (CnIs) are effective immunosuppressants with decades of accumulated experience in treating immune disorders and, most notably, solid organ transplantation. While CnIs have significantly increased graft survival and transformed the patient standard of care, their use has been overshadowed by a number of undesired side ...
Mesut Berber, David Penton
wiley   +1 more source

FDA's stamp of approval: Unveiling peptide breakthroughs in cardiovascular diseases, ACE, HIV, CNS, and beyond

Journal of Peptide Science, Volume 30, Issue 11, November 2024.
This review provides an overview of FDA‐approved peptides, particularly those targeting cardiovascular diseases, human immunodeficiency, and central nervous system diseases, and also addresses conditions such as osteoporosis, thrombocytopenia, Cushing's disease, and hypoglycemia.
Othman Al Musaimi
wiley   +1 more source

Anticancer therapeutic potential of genus Diospyros: From phytochemistry to clinical applications—A review

Food Science &Nutrition, Volume 12, Issue 10, Page 7033-7047, October 2024.
The Genus Diospyros has garnered significant scientific interest due to its diverse bioactivities, attributed to various phytochemicals like flavonoids, terpenoids, and xanthones. Several species, including D. lotus, D. kaki, and D. tricolor, exhibit promising anti‐cancer properties through in vitro and in vivo studies, demonstrating inhibition of ...
Abdur Rauf, Zuneera Akram, Nabia Hafeez, Anees Ahmed Khalil, Ahood Khalid, Zoya Abid, Hassan A. Hemeg, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Mohammed Mansour Quradha   +9 more
wiley   +1 more source

Intraosseous Venous Malformation of the Rib With EWSR1-NFATC1 Fusion Mimicking Malignancy: A Pediatric Case Report. [PDF]

J Pediatr Hematol Oncol
McCarty B, Gochnauer H, Longstaff X, Labib A, Naheedy J, Kulatti A, Mo JQ, Ellington N, Ding H, Lee K, Keller B, Eichenfield D, Schiff D.   +12 more
europepmc   +1 more source