Results 201 to 210 of about 23,374 (217)

NFKB1 –94 Insertion/Deletion ATTG Polymorphism in Gastroenteropancreatic Neuroendocrine Tumors

Chemotherapy, 2009
Nuclear factor-κB (NF-κB) is a transcription factor responsible for modulating the expression of many genes involved in immune response, inflammatory process, cell growth and survival. A functional and common promoter polymorphism of the NF-κB1 (NFKB1) gene leads to alteration in the activation pattern and expression of NF-κB, and thus, is probably ...
Ferda Sevimli, Burnik, Suayib, Yalçin
openaire   +2 more sources

RETRACTED: NFKB1 mediates Th1/Th17 activation in the pathogenesis of psoriasis

Cellular Immunology, 2018
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor and the authors, following concerns raised in the public domain.
Fusheng, Zhou, Zhengwei, Zhu, Jinping, Gao, Chao, Yang, Leilei, Wen, Lu, Liu, Xianbo, Zuo, Xiaodong, Zheng, Yinjuan, Shi, Caihong, Zhu, Bo, Liang, Xianyong, Yin, Wenjun, Wang, Hui, Cheng, Songke, Shen, Xianfa, Tang, Huayang, Tang, Liangdan, Sun, Anping, Zhang, Sen, Yang, Xuejun, Zhang, Yujun, Sheng   +21 more
openaire   +2 more sources

A new avenue for molecular glues: Rapid discovery of a NFKB1 degrader

Cell Chemical Biology, 2023
Targeted protein degradation using molecular glues is a powerful method for targeting traditionally undruggable proteins. One challenge in molecular glue discovery is the absence of rational discovery methods. Here, King et al. leverage covalent library screening with chemoproteomics platforms to rapidly discover a molecular glue targeting NFKB1 via ...
Angela T, Fan, Bridget T, Boyle, Fleur M, Ferguson   +2 more
openaire   +2 more sources

Dominant NFKB1 Mutations Cause Antibody Deficiency and Autoinflammatory Episodes

Blood, 2015
Abstract The NFkB signaling pathway is a master regulator of the immune response. Recently, dominant mutations in NFKB2 have shown to cause antibody deficiency with adrenal insufficiency. We investigated two families with antibody deficiency and autoinflammatory features, with onset in teenage years and early adulthood ...
Emma M Haapaniemi, Meri Kaustio, Helka Nurkkala, Merja Helminen, Satu Mustjoki, Einarsdottir Elisabet, Sahu Biswajyoti, Sanna Kilpinen, Jaana Syrjänen, Samuli Rounioja, Christopher Fogarty, Virpi Glumoff, Petri Kulmala, Shintaro Katayama, Fitsum Tamene, Timi Martelius, Luca Trotta, Ekaterina Morungova, Jussi Taipale, Janna Saarela, Juha Kere, Markku Varjosalo, Mikko Seppänen   +22 more
openaire   +1 more source

NFKB1-miR-612-FAIM2 pathway regulates tumorigenesis in neurofibromatosis type 1

In Vitro Cellular & Developmental Biology - Animal, 2019
Neurofibromatosis type I (NF1) is a carcinoma mainly featured by malignant peripheral nerve sheath tumor (MPNST). Dysregulated microRNAs (miRNAs) play decisive roles in tumor initiation and development. Our study sought for the possible roles of miR-612 in NF1.
Meng Wang, Zengtao Wang, Xiaolei Zhu, Shibing Guan, Zhibo Liu   +4 more
openaire   +2 more sources

Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype

Oncogene, 2017
Diffuse large B-cell lymphoma (DLBCL) has been categorized into two molecular subtypes that have prognostic significance, namely germinal center B-cell like (GCB) and activated B-cell like (ABC). Although ABC-DLBCL has been associated with NF-κB activation, the relationships between activation of specific NF-κB signals and DLBCL phenotype remain ...
X, Guo, J L, Koff, A B, Moffitt, M, Cinar, S, Ramachandiran, Z, Chen, J M, Switchenko, M, Mosunjac, S G, Neill, K P, Mann, M, Bagirov, Y, Du, Y, Natkunam, H J, Khoury, M R, Rossi, W, Harris, C R, Flowers, I S, Lossos, L H, Boise, S S, Dave, J, Kowalski, L, Bernal-Mizrachi   +21 more
openaire   +2 more sources

A Functional Promoter Polymorphism inNFKB1Increases Susceptibility to Endometriosis

DNA and Cell Biology, 2010
Numerous proinflammatory cytokines, such as TNFalpha and IL-6, which are nuclear factor kappaB (NF-kappaB) target genes, have been shown to promote proliferation in endometriotic cells, and several other genes involved in promoting growth are also NF-kappaB target genes. The aim of this study was to investigate whether the functional insertion/deletion
Bin, Zhou, Li, Rao, Ying, Peng, Yanyun, Wang, Mingrong, Qie, Zhu, Zhang, Yaping, Song, Lin, Zhang   +7 more
openaire   +2 more sources

HLA, NFKB1 and NFKBIA Gene Polymorphism Profile in Autoimmune Diabetes Mellitus Patients

Experimental and Clinical Endocrinology & Diabetes, 2007
Type 1 diabetes mellitus (T1DM) is one of the long-time studied autoimmune disorders. The triggering of the autoimmune process has been ascribed to various genes active in the regulation of the cytokine gene transcription including the Rel/NF-kappaB gene family.
K, Katarina, P, Daniela, N, Peter, R, Marianna, C, Pavlina, P, Stepanka, L, Jan, T, Ludmila, A, Michal, C, Marie   +9 more
openaire   +2 more sources

MULTI-ORGAN DISEASE ASSOCIATED WITH NFKB1 MUTATION

CHEST, 2023
SHARON ZHAO, CHRISTOPHER KING, CHRISTOPHER A THOMAS, SHAMBHU ARYAL, ANJU L SINGHAL, TIFFANY B GHAFOURI, FASIKA WELDEAREGAY, EASA AL-GHANDOUR, VAUGHAN WASHCO, MEGAN E TEREK, NICHOLAS MONTANO, VIKRAMJIT KHANGOORA   +11 more
openaire   +1 more source

Autosomal dominant NFKB1 haploinsufficiency and family planning

Clinical Immunology, 2023
Katrina Hannett, Stacey Hauk, Shannon Fowler, Barbara McGoey, Juan Ravell   +4 more
openaire   +1 more source