Results 121 to 130 of about 75,783 (261)

USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies

Annals of the New York Academy of Sciences, EarlyView.
USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge, Hongying Sun, Jia Zhang, Yang Yang, Jian Mao, Cheliger   +5 more
wiley   +1 more source

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, Andrew F. James, Svetlana Mastitskaya   +2 more
wiley   +1 more source

NFT TRGOVINA [PDF]

, 2022
In this final paper, an NFT marketplace is created on the Ethereum blockchain with an additional function of randomly generating an image according to the image layers. Within the NFT marketplace itself, users will create their own NFTs, review already created NFTs, sell and review past activities within the store. The Solidity programming language was
openaire  

The link between sarcopenic obesity and Alzheimer's disease: a brain‐derived neurotrophic factor point of view

The Journal of Physiology, EarlyView.
Abstract figure legend A, Sarcopenic obesity is defined as the age‐related loss of skeletal muscle mass and function that often leads to the progression of comorbidities, such as Alzheimer's disease (AD). Though the exact link between the two diseases is unknown, alterations in brain‐derived neurotrophic factor (BDNF) may be a contributor.
Emily N. Copeland, Paul J. LeBlanc, Paula Duarte‐Guterman, Val A. Fajardo, Rebecca E. K. MacPherson   +4 more
wiley   +1 more source

Blockchain for the Arts and Humanities

Future Humanities, Volume 4, Issue 1, May 2026.
ABSTRACT As born‐digital cultural materials proliferate, the arts and humanities require infrastructures that guarantee provenance, authenticity, and equitable access. This paper delivers a comprehensive, critical survey of blockchain's potential and limits across the sector.
James O'Sullivan
wiley   +1 more source

Field assessment of nitrogen sources in Brassica carinata using physiological indicators of nitrogen status under temperate no‐till conditions

Agrosystems, Geosciences &Environment, Volume 9, Issue 1, March 2026.
Abstract Improving nitrogen (N) use efficiency in Brassica carinata is essential to sustain yield and lower biofuel carbon intensity under variable field conditions. We hypothesized that integrating physiological indicators, such as the nitrogen nutrition index (NNI) and the critical nitrogen uptake curve (CriNUC), into N management frameworks would ...
Sebastián Bonansea, Oswaldo Ernst, Pablo González Barrios, Sebastián R. Mazzilli   +3 more
wiley   +1 more source

The Adler $D$-function for ${\cal N}=1$ SQCD regularized by higher covariant derivatives in the three-loop approximation

, 2017
We calculate the Adler $D$-function for ${\cal N}=1$ SQCD in the three-loop approximation using the higher covariant derivative regularization and the NSVZ-like subtraction scheme. The recently formulated all-order relation between the Adler function and
Kataev, A. L., Kazantsev, A. E., Stepanyantz, K. V.   +2 more
core   +2 more sources

A unified 3D reconstruction of microscopy and MRI in a brain showing Alzheimer's disease‐related neuropathology

Brain Pathology, Volume 36, Issue 2, March 2026.
Post mortem MRI was combined with neuropathological assessments at 600 μm intervals throughout the brain. Through this approach, a three dimensional account of an entire human brain with an intermediate Alzheimer's disease neuropathologic change was created.
Anneke Alkemade, Pierre‐Louis Bazin, Evgeniya Kirilina, Kerrin Pine, Andreas Herrler, Ronald L. A. W. Bleijs, J. Max Kros, Lysanne Groenewegen, Sanne M. M. Vermorgen, Laura E. Jonkman, Dick F. Swaab, Rawien Balesar, Nikolaus Weiskopf, Birte U. Forstmann   +13 more
wiley   +1 more source

Sialylation patterns in cerebral amyloid angiopathy

Brain Pathology, Volume 36, Issue 2, March 2026.
This study is the first to localize and evaluate sialylation modifications in the context of Alzheimer's Disease and Cerebral Amyloid Angiopathy, revealing a unique disease‐specific increase in intravascular sialylation. Abstract Glycosylation is the most common form of post‐translational modification in the brain and becomes significantly altered in ...
Caitlyn Fastenau, Rebecca Crisp, Mallory Keating, Elizabeth Ochoa, Timothy E. Richardson, Margaret E. Flanagan, Jamie M. Walker, Sarah C. Hopp, Kevin F. Bieniek   +8 more
wiley   +1 more source

Immunocytochemical Evidence that the B-Protein Precursor is an Integral Component of Neurofibrillary Tangles of Alzheimer\u27s Disease [PDF]

, 1993
Amyloid B (AB) immunoreactivity has been demonstrated in all extracellular neurofibrillary tangles (E-NFT) and most intraneuronal neurofibrillary tangles (I-NF.
Dewitt, David A.
core