Results 121 to 130 of about 24,952 (199)

Structural compression and entorhinal vulnerability: Linking tentorial adjacency to tau burden and dementia progression

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Early neurofibrillary tau degeneration in the entorhinal cortex (EC) is a hallmark of Alzheimer's disease (AD) and aging. We propose a biomechanical cascade hypothesis, suggesting proximity to the tentorial incisura (TI) may render the EC susceptible to chronic mechanical stress, potentially contributing to tau pathology.
Luyue Zhang, Ana M. Franceschi, John F. Crary, Frank A. Provenzano, for the Alzheimer's Disease Neuroimaging Initiative   +4 more
wiley   +1 more source

Conjoint analysis of key determinants of consumer purchase intentions for profile picture non-fungible tokens

Humanities & Social Sciences Communications
Since 2021, interest in non-fungible tokens (NFTs) and associated trading volume have increased substantially, as celebrities increasingly adopted profile picture non-fungible tokens (PFP NFTs) for their social media profile images.
Yongki Baek, Joohee Kim, Daeho Lee, Jungwoo Shin, Yunseon Na, Mideum Choi   +5 more
doaj   +1 more source

Cognitive impairment in Parkinson disease correlates with loss of cholinergic axon projections to cortex in an autopsy study

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION People with Parkinson's disease (PD) frequently develop dementia. We investigated the relationship between cognitive impairment and the loss of cholinergic axon projections from the nucleus basalis of Meynert to neocortical regions in PD.
Rebecca Miller, Jennifer O'Shea, Laura M. Rosok, Sydney Lim, Erin E. Franklin, Richard J. Perrin, Helen Hwang, Dhruva Dhavale, Joel Perlmutter, Meghan C. Campbell, Paul Kotzbauer   +10 more
wiley   +1 more source

Dеmystification of propеrty rights in thе contеxt of thе digital transformation of thе еconomy

RUDN Journal of Law
Thе rеsеarch rеlеvancе liеs in thе intеrsеction of thе classical civil problеm of thе lеgal naturе of propеrty rights and thе еvolving landscapе of digital tеchnologiеs, which has givеn risе to propеrty rights taking on a digital form (digital rights ...
Anatoly V. Efimov
doaj   +1 more source

Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System

Annals of Neurology, Volume 100, Issue 4, Page 709-736, October 2026.
Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti, Nicolas R. Barthélemy, Kanta Horie, Cindy V. Ly, Kaleigh F. Roberts, Srinivas Koutarapu, Richard J. Perrin, Erin E. Franklin, Chiara Pedicone, Joshua Orrick, Justin Melendez, Timothy M. Miller, Chihiro Sato, Nupur Ghoshal, Alison M. Goate, Celeste M. Karch, Randall J. Bateman, Soumya Mukherjee   +17 more
wiley   +1 more source

Valuation and Volatility of Virtual Properties in Metaverse: Exploring New Market Opportunities and Speculative Dynamics Based on Decentraland

Journal of Metaverse
Existing reality has been repeatedly subjected to multifaceted and multidimensional analyses. However, alongside it, a virtual reality exists, populated with virtual art, objects in games, cyber-pets, and virtual properties, collectively worth billions ...
Dawid Narowski, Celso Santos, Lukasz Borowski, Michal Apollo, Kamil Maciuk   +4 more
doaj   +1 more source

Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease

BioEssays, Volume 48, Issue 10, October 2026.
Recent human genetic studies highlight the critical role of microglial pathways in Alzheimer's disease, with risk loci enriched in microglia‐specific genes such as SPI1 and MEF2C. Dysregulation of these transcription factors contributes to disease pathogenesis.
Byungwook Kim, Selena S. Wang, Justin R. Kim, Jungsu Kim   +3 more
wiley   +1 more source

Beyond Content Digitization: A Smart Contract‐Based Solution for Ownership and Motivation in Online Learning (Course‐Chain)

Journal of Computer Assisted Learning, Volume 42, Issue 5, October 2026.
ABSTRACT Introduction With the advancement of the digital age, traditional face‐to‐face education and training programs have been increasingly replaced by online courses, which consist of live digital lectures and pre‐recorded video content. However, although online course platforms have succeeded in digitizing the essential requirements of traditional
Süleyman Can Tuğcu, Murtaza Cicioğlu, Ali Çalhan   +2 more
wiley   +1 more source

Lynn University NFT Art Museum Student Showcase

Cesar Santalo, Dean of the College of Communication and Design, and Dr. Andrew Corsa, Associate Professor, College of Arts and Sciences, collaborated to organize an exhibit of student artwork in the metaverse: The Lynn University NFT Art Museum Student ...
Andrews, Belle, Mayhew, Cahris, Santalo, Gabriel, Rowland, Bodie, Gordon, Candace, Terry, Fred, Rowland, Natalie, Middleton, Joshua, Madison, Joshua, Oliver, Nat, Phipps, Nautica, Rose, Shona, Woodstock, Amber   +12 more
core  

Genetic and Pharmacological Targeting of Hsp72 Overexpression/Induction in an Alzheimer's Disease Mouse Model With Combined Amyloid and Tau Pathology

Journal of Neuroscience Research, Volume 104, Issue 10, October 2026.
We investigated targeting Hsp72 protein expression genetically and via a drug, in a model of combined amyloid and tau pathology. Neither approach reduced amyloid or tau or improved body composition or movement ability. Both treatments tended to slightly improve survival in male mice and anxiety‐like behavior in female mice.
J. P. S. Marshall, A. Harutyunyan, J. Ng, O. M. West, J. M. Collins, A. E. King, J. Morizzi, P. Wright, A. C. Calkin, B. G. Drew, N. C. Jones, P. A. Adlard, M. A. Febbraio, D. C. Henstridge   +13 more
wiley   +1 more source