Results 131 to 140 of about 7,513 (165)

Circadian-Rhythm-dependent Effects of L-N^G-Nitroarginine Methyl Ester (L-Name) on Morphine-Induced Analgesia

Chronobiology International, 1998
Circadian changes in the interactions between L-NG-nitroarginine methyl ester (L-NAME), a nitric oxide synthase (NOS) inhibitor, and morphine-induced antinociception were investigated by the mouse hot-plate test. Both the basal pain sensitivity and morphine-induced analgesia undergo significant 24 h variations.
Uludag, O, Guney, HZ, Zengil, H, Gorgun, CZ, Hodoglugil, U, Tunctan, B, Abacioglu, N   +6 more
openaire   +4 more sources

The influence of L-N G -nitroarginine methyl ester, an inhibitor of nitric oxide synthase, upon the anticonvulsive activity of conventional antiepileptic drugs against maximal electroshock in mice

Journal of Neural Transmission, 1998
NG-Nitro-L-arginine methyl ester (L-NAME, an unspecific nitric oxide synthase inhibitor), applied at 1 and 40 mg/kg, did not influence the electroconvulsive threshold, but impaired the anticonvulsant activity of valproate (at 40 mg/kg) and phenobarbital (at 1 and 40 mg/kg). No effect was observed in the case of carbamazepine and diphenylhydantoin.
K K, Borowicz, R, Starownik, Z, Kleinrok, S J, Czuczwar   +3 more
openaire   +3 more sources

13. Anti-inflammatory role of L-NG-Nitroarginine Methyl Ester in a chronic model of depression

Brain, Behavior, and Immunity, 2013
The role of nitric oxide (NO) in the neurodegenerative disorders is well illustrated. The close relationship of NO level and the inflammation points out the clinical relevance of NO in depressive disorder. Present study evaluated the neuroprotective role of L-NAME, a NO synthase blocker in chronic restraint hypoxia (CRH) induced depressive behaviour ...
S. DEEP, A. Sharma, I. Baitharu, V. Jain, D. Prasad, S.B. Singh   +5 more
openaire   +2 more sources

Estrogen-induced uterine vasodilatation is antagonized by L-nitroarginine methyl ester, an inhibitor of nitric oxide synthesis

American Journal of Obstetrics and Gynecology, 1992
G. V. Buren, D. Yang, Kenneth E. Clark
exaly   +2 more sources

L-NAME (NG-nitroarginine methyl ester) establishes foetal growth restriction and induces structural and functional lung changes in a multi-insult animal model of bronchopulmonary dysplasia

Molecular pathology and functional genomics
Marnel Greyling, Jaan Toelen, Yannick Regin, Emilie Goffinon   +3 more
openaire   +2 more sources

1,8-Cineole ameliorates endothelial injury and hypertension induced by L-NAME through regulation of autophagy via PI3K/mTOR signaling pathway.

European Journal of Pharmacology, 2023
Our previous data confirmed that 1,8-Cineole had an antihypertensive effect in animal models. However, it is unclear whether antihypertension is dependent on the protective effect of 1,8-Cinceole on endothelial function and structure.
Meng-Jinn Chen, Qilan Hu, Shengquan Wang, L. Tao, Xiao-xia Hu, Xiang-chun Shen   +5 more
semanticscholar   +1 more source

Protective effect of minocycline on LPS-induced mitochondrial dysfunction and decreased seizure threshold through nitric oxide pathway.

European Journal of Pharmacology, 2019
Lipopolysaccharide (LPS) increases inflammatory cytokines of the brain and deregulates the mitochondrial function, thus could increase the seizure susceptibility. Studies have shown that minocycline has neuroprotective and antioxidant properties. In this
A. Haj-Mirzaian, K. Ramezanzadeh, Armin Tafazolimoghadam, Kiarash Kazemi, Rajan Nikbakhsh, Rambod Nikbakhsh, H. Amini-khoei, Khashayar Afshari, Nazgol-Sadat Haddadi, S. Shakiba, Fahimeh Azimirad, S. Mousavi, A. Dehpour   +12 more
semanticscholar   +1 more source

Repeat administration of human umbilical cord mesenchymal stem cells improves left ventricular diastolic function in mice with heart failure with preserved ejection fraction.

Biochemical and Biophysical Research Communications - BBRC
Currently, no therapy is proven to effectively improve heart failure with preserved ejection fraction (HFpEF). Although stem cell therapy has demonstrated promising results in treating ischemic heart disease, the effectiveness of treating HFpEF with ...
Yunzhen Feng, Yuanfeng Xin, Wenjie Tang, Pengfei Zhang, Hong Zhu, Hao Li, Y. Gong, Feng Chen, Zhifeng Xu, Zhongmin Liu, Ling Gao   +10 more
semanticscholar   +1 more source

Combined vaccines against angiotensin II receptor type 1 and alpha 1D-adrenergic receptor for hypertension

Journal of Hypertension
Purpose: Compared with monotherapy, combination therapy with multiple antihypertensive drugs has demonstrated superior efficacy in the management of hypertension.
Jiacheng Wu, Zhijie Wu, Wenlong Kuang, D. Shi, Yulu Yang, Xin Li, Jianwu Huang, Xuehan Li, Yuhua Liao, Zihua Zhou, Zhihua Qiu   +10 more
semanticscholar   +1 more source

Impaired Midkine/Treg Signaling Contributes to Pathogenesis of Preeclampsia

HYPERTENSION
Early-onset preeclampsia is characterized by maternal-fetal immune dysregulation and trophoblast dysfunction, commonly presenting with a reduction in regulatory T cells (Tregs) and impaired trophoblast invasion.
Liqun Lou, Ye Chen, Shengyi Gu, Jingrong Chen, Yan Lu, Junlong Dang, S. Qin, Sheng Wan, Chenchen Zhou, Weijia Luo, Wenxi He, S. Zheng, Xiaolin Hua   +12 more
semanticscholar   +1 more source