Results 61 to 70 of about 1,649 (145)

The space network evolution of green development and its multidimensional network location analysis: Under the Chinese scenario

Ecological Indicators
Green development (GD) has emerged as a key area of focus for the sustainable development in the new era. Discussing spatial correlation networks and their multidimensional location impact on GD is of paramount significance for facilitating spillover ...
Xiao Dai, Yue Zhang
doaj   +1 more source

Structural and Functional Connectivity in Parkinson's Disease Patients With Freezing of Gait and Other Gait Disturbances

Clinical Neuroimaging
Background Freezing of gait (FoG) is a debilitating motor feature that affects individuals with Parkinson's disease (PD). The mechanism underlying FoG is not entirely understood, which poses a challenge in finding effective treatment.
Quynh Le, Arichena Manmatharayan, Mashaal Syed, Kichang Kang, Tsao‐Wei Liang, Mahdi Alizadeh, Chengyuan Wu   +6 more
doaj   +1 more source

Development and evaluation of a patient-reported outcome measure specific for Gaucher disease with or without neurological symptoms in Japan

Orphanet Journal of Rare Diseases
Background Patients with Gaucher disease (GD), a rare lysosomal storage disorder, have reduced health-related quality of life (HRQOL). A patient-reported outcome measure (PROM) for HRQOL developed for type 1 GD (GD1) is not appropriate for patients with ...
Aya Narita, Yuta Koto, Shinichi Noto, Masafumi Okada, Midori Ono, Terumi Baba, Rieko Sagara, Norio Sakai   +7 more
doaj   +1 more source

Linking Patient-Reported Outcomes and Housing Data to Inform Breathlessness Service Planning in Wales

International Journal of Population Data Science
Breathlessness is common among individuals with chronic conditions and is influenced by clinical and environmental factors. Cold, damp and poorly insulated housing is linked to poorer health, especially among those with respiratory or circulatory ...
Sally Cox, Alexander Shaw, Rory Prentice, Lloyd John, Nichola Thuvesholmen, Sarah Puntoni, Jessica Scrimshire, Sophie Franckel   +7 more
doaj   +1 more source

Stalled disomes marked by Hel2-dependent ubiquitin chains undergo Ubp2/Ubp3-mediated deubiquitination upon translational run-off

Communications Biology
Stalled ribosomes cause collisions, impair protein synthesis, and generate potentially harmful truncated polypeptides. Eukaryotic cells utilize the ribosome-associated quality control (RQC) and no-go mRNA decay (NGD) pathways to resolve these problems ...
Mario Scazzari, Ying Zhang, Anna Moddemann, Sabine Rospert   +3 more
doaj   +1 more source

Brain structural volume changes and gait disorders in patients with cerebral small vessel disease: a principal component and logistic regression analysis

BMC Medical Imaging
Aims To investigate the relationship between the relative volume changes of brain structures and gait disorders in patients with cerebral small vessel disease (CSVD), and to identify key brain volume indicators that influence gait disorders (GD) through ...
Hong-Bo Wang, Hua-Wei Chen, Xiao-Ying Zhao, Jia-Jing Tian, Bing-Bing Gao, Yan-Wei Miao, Bing-Wei Zhang   +6 more
doaj   +1 more source

Consensus-based framework for assessing social prescribing schemes in primary healthcare

BMC Primary Care
Background Social Prescribing Schemes (SPS) incorporate community-based activities (Health Assets, HAs) into primary healthcare (PHC) to address social determinants of health and enhance well-being.
A. M. Carrera-Noguero, M. Guilabert Mora, V. Pérez-Jover, M. Pola-Garcia, J. J. Mira Solves, M. P. Astier-Peña, Consortium EvaLRA   +6 more
doaj   +1 more source

Thermodynamic natural gradient descent (NGD-T) regulates natural-gradient steps by a geometric speed-cost bound. [PDF]

Sci Rep
You BJ.
europepmc   +1 more source

Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies. [PDF]

Elife
Lin Y, Liou B, Fannin V, Adler S, Mayhew CN, Hammonds JE, Hu YC, Tchieu J, Zhang W, Zhao X, Beres RL, Setchell KDR, Kaynak A, Qi X, Feldman RA, Sun Y.   +15 more
europepmc   +1 more source

From Lysosomal Storage to Neurodegeneration: Sphingolipid Signaling as a Driver of CNS Pathology and Biomarker Strategy in Neuronopathic Gaucher Disease. [PDF]

Int J Mol Sci
Casazza K, Kartha RV, Jarnes JR.
europepmc   +1 more source