Results 241 to 250 of about 94,176 (342)

NGF processing

Reactome - a curated knowledgebase of biological pathways, 2007
S Nasi, D Annibali
openaire   +1 more source

Icariside II in Neurological Disorders: Mechanistic Insights Into Alzheimer's Disease, Cerebral Ischemia and Parkinson's Disease

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
The graphical abstract represents the underlying neuroprotective potential of ICS II against Alzheimer's disease, Cerebral ischemia and Parkinson disease. ICS II downregulates ROS production, inflammation, mitochondrial dysfunction and apoptosis along with regulating their key signalling pathways.
Ashutosh Solanki, Khushi Sharma, Jagrati Jain, Niraj Kumar Singh, Praveen T. Krishnamurthy   +4 more
wiley   +1 more source

Ethanol selectively disrupts neuronal microexon regulation and chromatin marks in PC12 cells. [PDF]

Front Cell Neurosci
Olivares-Costa M, Jorratt P, Morales C, Estay SF, Krainer AR, Andrés ME, Haeger PA.   +6 more
europepmc   +1 more source

Heparan Sulfate Proteoglycans: Master Regulators of Cellular Signaling, Tissue Development, and Neural Function

Journal of Neuroscience Research, Volume 104, Issue 9, September 2026.
Ubiquitous cell‐associated, cytoplasmic, synaptic and extracellular matrix HS‐proteoglycans are multifunctional regulators of tissue form and function. HS‐proteoglycans have diverse functions as growth factor co‐receptors in cell proliferation, differentiation, tissue development, mechanical stabilization, synaptogenesis, synaptic plasticity, and ...
James Melrose
wiley   +1 more source

Transcriptomic Signature of PDGF-BB Control of Annulus Fibrosus Reveals Modulation of Inflammatory and Neurogenic Pathways. [PDF]

Cells
Zhang C, Gu G, McNulty JW, Berenfeld D, Haglund L, Yoon ST, Goh B, Drissi H.   +7 more
europepmc   +1 more source

Addressing Overlooked Variables in Preclinical Fracture Repair Research for Improved Translation

Journal of Orthopaedic Research, Volume 44, Issue 9, September 2026.
ABSTRACT In preclinical research focused on bone fracture repair, a significant gap exists in understanding and incorporating key variables that influence homeostasis and pathophysiological processes. Factors such as immune system responses, sex differences, pain and innervation, and microbiota are often overlooked.
Christina Capobianco, Katharina Schmidt‐Bleek, Melanie Haffner‐Luntzer, Chelsea Bahney, Joseph L. Roberts, Matthew J. Silva, Annemarie Lang   +6 more
wiley   +1 more source

Perineural Invasion, Pain and Immunosuppression Across Solid Tumours. [PDF]

Curr Oncol
Dybcio P, Kuraś A, Dyrka M, Iwaszko M, Pec J, Kleinrok J, Korolczuk A.   +6 more
europepmc   +1 more source

Lost in Translation: Why Biologic Therapies for Intervertebral Disc Degeneration and Low Back Pain Have Not Reached the Clinic (Yet)

JOR SPINE, Volume 9, Issue 3, September 2026.
From preclinical promise to clinical translation in intervertebral disc degeneration (IDD). Robust preclinical evidence supports a range of biologic therapies, with consistent improvements in imaging, extracellular matrix composition, inflammation, and behavior.
Luca Ambrosio, Jordy Schol, Clara Ruiz‐Fernandez, Vincenzo Denaro, Gianluca Vadalà, Daisuke Sakai   +5 more
wiley   +1 more source

Nerve growth factor responsive elements modulate immune cell inflammation and are dysregulated in an Alzheimer's disease mouse model. [PDF]

Front Immunol
Gera R, Mocci G, Tambaro S, Vanlandewijck M, Nilsson P, Eriksdotter M, Mitra S.   +6 more
europepmc   +1 more source

A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain‐Inducing Nucleus Pulposus Cell Emergence

JOR SPINE, Volume 9, Issue 3, September 2026.
A porcine model of disc injury recapitulates key clinical, histological, and molecular features of human discogenic low back pain. Multi‐omics analyses identify a shift from notochordal cells to pain‐associated nucleus pulposus cells as a potential driver of disease progression. ABSTRACT Background Lower back pain (LBP) is one of the most common causes
Giselle Kaneda, Jacob T. Wechsler, Melissa Chavez, Julia Sheyn, Karandeep Cheema, Chushu Shen, Dante Rigo De Righi, Lixia Wang, Yin‐Chen Hsu, Pablo Avalos, Yibin Xie, Wafa Tawackoli, Candace Floyd, Debiao Li, Dmitriy Sheyn   +14 more
wiley   +1 more source