Results 61 to 70 of about 927,461 (351)
The South African wildlife ranching sector: A Social Accounting Matrix Leontief multiplier analysis
Acta Commercii, 2014 Orientation: There is startlingly little economic research on the South African wildlife sector which contributes toward disputes regarding the economic contribution of the sector.
Philippus C. Cloete, Riaan Rosouw
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
mSphereGlycerol dithionomonolaurate (NB2) is an analog of the natural antimicrobial compound glycerol monolaurate (GML) with enhanced antimicrobial activity.
Patrick M. Schlievert +3 more
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Gênero e raça sob enfoque decolonial [PDF]
Sociologias, 2022 Alex Niche Teixeira, Enio Passiani
doaj +1 more source
Science and Technology of Advanced MaterialsWe performed resonance shear measurements (RSM) using the low-temperature surface force apparatus (LT-SFA) to investigate how rubber composition influences the viscoelasticity of the rubber-ice interface.
Michael C. Stevens +3 more
doaj +1 more source
Niche shifts after long-distance dispersal events in bipolar sedges (Carex, Cyperaceae) [PDF]
, 2017 PREMISE OF THE STUDY: Bipolar species represent the greatest biogeographical disjunction on Earth, raising many questions about the colonization and adaptive processes behind such striking distribution.
Escudero Lirio, Marcial +3 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Circumbinary habitability niches [PDF]
International Journal of Astrobiology, 2014 AbstractBinaries could provide the best niches for life in the Galaxy. Although counterintuitive, this assertion follows directly from stellar tidal interaction theory and the evolution of lower mass stars. There is strong evidence that chromospheric activity of rapidly rotating young stars may be high enough to cause mass loss from atmospheres of ...
Mason, Paul A. +3 more
openaire +4 more sources