Results 61 to 70 of about 252,702 (266)

The Nexus Between Plant and Plant Microbiome: Revelation of the Networking Strategies

Frontiers in Microbiology, 2020
The diversity of plant-associated microbes is enormous and complex. These microbiomes are structured and form complex interconnected microbial networks that are important in plant health and ecosystem functioning.
Olubukola Oluranti Babalola, Ayomide E. Fadiji, Ben J. Enagbonma, Elizabeth T. Alori, Modupe S. Ayilara, Ayansina S. Ayangbenro   +5 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Developmental differences in higher-order resting-state networks in Autism Spectrum Disorder

NeuroImage: Clinical, 2014
Objective: Autism Spectrum Disorder (ASD) has been associated with a complex pattern of increases and decreases in resting-state functional connectivity.
Dienke J. Bos, Tamar R. van Raalten, Bob Oranje, Anouk R. Smits, Nieke A. Kobussen, Janna van Belle, Serge A.R.B. Rombouts, Sarah Durston   +7 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Preliminary Prevalence of Vitamin D and Iron Deficiency in Healthy Primary School Children

Proceedings
Nutritional deficiencies in iron and vitamin D are common in children at a global level, albeit they can be overlooked in apparently healthy children.
Emily Royle, Kirsty Pourshahidi, Emeir McSorley, Pamela Magee   +3 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Can we use neuroimaging data to differentiate between subgroups of children with ADHD symptoms: A proof of concept study using latent class analysis of brain activity

NeuroImage: Clinical, 2019
Background: Multiple pathway models of ADHD suggest that multiple, separable biological pathways may lead to symptoms of the disorder. If this is the case, it should be possible to identify subgroups of children with ADHD based on distinct patterns of ...
Aleksandra Lecei, Branko M. van Hulst, Patrick de Zeeuw, Marieke van der Pluijm, Yvonne Rijks, Sarah Durston   +5 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

P1338: VASCULARIZED BONE MARROW-ON-CHIP TO STUDY VASCULAR ABERRATION IN HEMATOPOIETIC DISEASES

HemaSphere, 2023
Thomas Bessy, Jessica Albuquerque, Jorgina Reginold, Lucas Sagnet, Giovanni Diana, Manuel Thery, Diana Passaro   +6 more
doaj   +1 more source

Is the Generation of Active Vitamin B6 Dependent upon Riboflavin Status? New Analysis of Data from RCTs of Riboflavin Supplementation

Proceedings
Background and objectives: Riboflavin in the form flavin mononucleotide (FMN) acts as a cofactor for the pyridoxine phosphate oxidase required to generate pyridoxal 5′-phosphate (PLP), the active form of vitamin B6 in tissues.
Ryan Barlow, Helene McNulty, Catherine Hughes, Kristina Pentieva, Geraldine Horigan, Yvonne Lamers, Mary Ward   +6 more
doaj   +1 more source