Results 61 to 70 of about 904,403 (306)

Languages adapt to their contextual niche [PDF]

open access: yes, 2014
It is well established that context plays a fundamental role in how we learn and use language. Here we explore how context links short-term language use with the long-term emergence of different types of language system.
Kirby, Simon   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Phylogenetic patterns of diversification across ecological niches in the African tree genus Guibourtia [PDF]

open access: yes, 2018
Adaptive evolution is thought to be a major driver of organism diversification but the link between phenotypic traits and environmental niche remains little documented in tropical trees.
Agbazahou, Honoré   +8 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

The South African wildlife ranching sector: A Social Accounting Matrix Leontief multiplier analysis

open access: yesActa Commercii, 2014
Orientation: There is startlingly little economic research on the South African wildlife sector which contributes toward disputes regarding the economic contribution of the sector.
Philippus C. Cloete, Riaan Rosouw
doaj   +1 more source

Ecology and co-existence of two endemic day gecko (Phelsuma) species in Seychelles native palm forest [PDF]

open access: yes, 2011
In island ecosystems, reptiles play diverse ecological roles as a result of niche broadening, which increases potential niche overlap between species. Ecological niche partitioning is a means of reducing direct competition between coexisting species and ...
Bassett   +30 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Determination of Plasmalogen Molecular Species in Hen Eggs

open access: yesMolecules
(1) Background: Plasmalogens are vinyl ether-type glycerophospholipids that are characteristically distributed in neural tissues and are significantly reduced in the brains of individuals with dementia compared to those in healthy subjects, suggesting a ...
Taiki Miyazawa   +3 more
doaj   +1 more source

E-Ras improves the efficiency of reprogramming by facilitating cell cycle progression through JNK–Sp1 pathway

open access: yesStem Cell Research, 2015
We have previously shown that pluripotent stem cells can be induced from adult somatic cells which were exposed to protein extracts isolated from mouse embryonic stem cells (mESC).
Yoo-Wook Kwon   +6 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

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