Results 341 to 350 of about 256,874 (388)

Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients.

New England Journal of Medicine, 2023
BACKGROUND Immunosuppressed organ-transplant recipients have an increased incidence of, and mortality from, skin cancer. Nicotinamide (vitamin B3) enhances the repair of ultraviolet (UV) radiation-induced DNA damage, reduces the cutaneous ...
Nicholas C Allen, Andrew J. Martin, V. Snaidr, Renee Eggins, A. Chong, P. Fernández-Peñas, D. Gin, S. Sidhu, V. Paddon, L. Banney, Adrian Lim, E. Upjohn, H. Schaider, Aparna D Ganhewa, Jennifer Nguyen, C. McKenzie, Saurabh Prakash, C. Mclean, A. Lochhead, J. Ibbetson, A. Dettrick, A. Landgren, Katherine J Allnutt, Clare Allison, Rachael B Davenport, Blake P Mumford, Brittany Wong, Brendan Stagg, Alexander Tedman, Hannah Gribbin, H. Edwards, Nicholas De Rosa, Thomas Stewart, B. Doolan, Y. Kok, K. Simpson, Z. Low, T. Kovitwanichkanont, R. Scolyer, H. Dhillon, J. Vardy, S. Chadban, David G Bowen, Andrew C Chen, D. Damian   +44 more
semanticscholar   +1 more source

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

Cell Metabolism, 2016
Alessia Grozio, Yo Sasaki, Philip Redpath   +2 more
exaly   +2 more sources

Systematic Engineering of Escherichia coli for Efficient Production of Nicotinamide Mononucleotide From Nicotinamide.

ACS Synthetic Biology, 2022
Research studies on NAD+ have proven its crucial role in aging and disease. Nicotinamide mononucleotide (NMN), as the key intermediate of NAD+, plays a significant role in supplying and maintaining NAD+ levels. In the present study, a biocatalytic method
Zhongshi Huang, Ning Li, Shiqin Yu, Weiping Zhang, Tianmeng Zhang, Jingwen Zhou   +5 more
semanticscholar   +1 more source

Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism

Frontiers in Cell and Developmental Biology, 2020
NAD+, a co-enzyme involved in a great deal of biochemical reactions, has been found to be a network node of diverse biological processes. In mammalian cells, NAD+ is synthetized, predominantly through NMN, to replenish the consumption by NADase ...
weiqi Hong, Fei Mo, Ziqi Zhang
exaly   +2 more sources

Nicotinamide and the skin

Australasian Journal of Dermatology, 2014
AbstractNicotinamide, an amide form of vitamin B3, boosts cellular energy and regulates poly‐ADP‐ribose‐polymerase 1, an enzyme with important roles in DNA repair and the expression of inflammatory cytokines. Nicotinamide shows promise for the treatment of a wide range of dermatological conditions, including autoimmune blistering disorders, acne ...
Andrew C. Chen, Diona L. Damian, Diona L. Damian   +2 more
openaire   +3 more sources

Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule

Biomolecules, 2019
Nicotinamide mononucleotide (NMN) is a nucleotide that is most recognized for its role as an intermediate of nicotinamide adenine dinucleotide (NAD+) biosynthesis.
Saikat Kumar Poddar, Noor Ahmed Nahid
exaly   +2 more sources

Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase

Bioorganic & Medicinal Chemistry Letters, 2018
Nicotinamide N-methyltransferase (NNMT) has been linked to obesity and diabetes. We have identified a novel nicotinamide (NA) analog, compound 12 that inhibited NNMT enzymatic activity and reduced the formation of 1-methyl-nicotinamide (MNA), the primary metabolite of NA by ∼80% at 2 h when dosed in mice orally at 50 mg/kg.
Sven Ruf, Mahanandeesha Siddappa Hallur, Nisha K. Anchan, Indu N. Swamy, Karthikai Raj Murugesan, Sayantani Sarkar, Lokesh Kananti Narasimhulu, V.P. Rama Kishore Putta, Shama Shaik, Devaraj Venkatapura Chandrasekar, Vishal Subhash Mane, Sanjay Venkatachalapathi Kadnur, Juluri Suresh, Ravi Kanth Bhamidipati, Manvi Singh, Raghunadha Reddy Burri, Rajendra Kristam, Herman Schreuder, Joerg Czech, Christine Rudolph, Alexander Marker, Thomas Langer, Ramesh Mullangi, Takeshi Yura, Ramachandraiah Gosu, Aimo Kannt, Saravanakumar Dhakshinamoorthy, Sridharan Rajagopal   +27 more
openaire   +3 more sources

Effect of Nicotinamide Administration on the Tryptophan-Nicotinamide Pathway in Humans

International Journal for Vitamin and Nutrition Research, 2007
The vitamin nicotinamide is synthesized in the liver from tryptophan, and distributed to non-hepatic tissues. Although it is generally accepted that 60 mg tryptophan is equivalent to 1 mg nicotinamide in humans, the conversion ratio of tryptophan to nicotinamide is changeable.
Tsutomu Fukuwatari, Katsumi Shibata
openaire   +3 more sources

Lipid Peroxidation in Nicotinamide-Deficient and Nicotinamide-Supplemented Rats

International Journal for Vitamin and Nutrition Research, 2000
Supplementation or deficiency of nicotinamide in rats may interfere with the oxidative balance, with excess leading to greater lipid peroxidation, measured by TBARS, and deficiency causing a greater consumption of antioxidants such as vitamin E and glutathione.
Hélio Vannucchi, Alceu Afonso Jordão, Sandra Melo, Mônica S. S. Meirelles   +3 more
openaire   +3 more sources

Nicotinamide in dermatology

Expert Review of Dermatology, 2010
Nicotinamide, also known as niacinamide or nicotinic acid amide, is the water-soluble, active form of vitamin B3. It has been increasingly studied for many different indications in the field of dermatology. Some studied attributes of niacinamide include the prevention of ultraviolet immunosuppression in both oral and topical formulations, anti ...
Nancy Kim, Robert S. Kirsner
openaire   +2 more sources